AI Article Synopsis
- The study aimed to systematically review and assess the effectiveness of sentinel lymph-node biopsy (SLNB) in women with node-positive breast cancer diagnosed and node-negative tumors after neoadjuvant therapy, comparing it to axillary lymph-node dissection.
- Key metrics analyzed included false-negative rate (FNR), sentinel lymph-node identification rate (SLNIR), negative predictive value (NPV), and overall accuracy through data from twenty relevant studies.
- Results showed that SLNB had a low FNR of 0.14 and high SLNIR of 0.89, indicating better outcomes especially when multiple nodes were removed and double mapping techniques were used.
Article Abstract
Purpose: To conduct a systematic review to analyse the performance of the sentinel lymph-node biopsy (SLNB) in women with node-positive breast cancer at diagnosis and node-negative tumour after neoadjuvant therapy, compared to axillary lymph-node dissection.
Methods: The more relevant databases were searched. Main outcomes were false-negative rate (FNR), sentinel lymph-node identification rate (SLNIR), negative predictive value (NPV), and accuracy. We conducted meta-analyses when appropriate.
Results: Twenty studies were included. The pooled FNR was 0.14 (95% CI 0.11-0.17), the pooled SLNIR was 0.89 (95% CI 0.86-0.92), NPV was 0.83 (95% CI 0.79-0.87), and summary accuracy was 0.92 (95% CI 0.90-0.94). SLNB performed better when more than one node was removed and double mapping was used.
Conclusions: SLNB can be performed in women with a node-negative tumour after neoadjuvant therapy. It has a better performance when used with previous marking of the affected node and with double tracer.
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| http://dx.doi.org/10.1007/s12094-022-02953-1 | DOI Listing |
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