AI Article Synopsis
- * A total of 177 infants were examined, with 68% of them successfully extubated; the model had an AUROC score of 0.72, indicating good predictive ability.
- * The results suggest that while the model performs acceptably in a different group, further studies are necessary to enhance its accuracy and clinical use.
Article Abstract
Objective: To perform an external validation of a publicly available model predicting extubation success in very preterm infants.
Study Design: Retrospective study of infants born <1250 g at a single center. Model performance evaluated using the area under the receiver operating characteristic curve (AUROC) and comparing observed and expected probabilities of extubation success, defined as survival ≥5 d without an endotracheal tube.
Results: Of 177 infants, 120 (68%) were extubated successfully. The median (IQR) gestational age was 27 weeks (25-28) and weight at extubation was 915 g (755-1050). The model had acceptable discrimination (AUROC 0.72 [95% CI 0.65-0.80]) and adequate calibration (calibration slope 0.96, intercept -0.06, mean observed-to-expected difference in probability of extubation success -0.08 [95% CI -0.01, -0.15]).
Conclusions: The extubation success prediction model has acceptable performance in an external cohort. Additional prospective studies are needed to determine if the model can be improved or how it can be used for clinical benefit.
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| http://dx.doi.org/10.1038/s41372-022-01517-z | DOI Listing |
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