AI Article Synopsis
- The study investigated the relationship between HDL-mediated cholesterol mass efflux capacity (CMEC) and coronary artery calcium (CAC) scores among participants in the Multi-Ethnic Study of Atherosclerosis (MESA).
- Despite measuring CMEC in over 1600 individuals and performing cardiac CT exams for CAC at multiple time points, the results showed no significant association between higher CMEC and lower CAC scores or increased CAC density.
- The findings imply that the role of HDL-mediated cholesterol efflux in cardiovascular risk may operate through pathways that do not directly involve the accumulation of calcified plaque in arteries.
Article Abstract
We assessed the cross-sectional and longitudinal relationships of high-density lipoprotein (HDL)-mediated cholesterol mass efflux capacity (CMEC) with coronary artery calcium (CAC) score and CAC density. CMEC was measured in 1626 Multi-Ethnic Study of Atherosclerosis (MESA) participants in samples obtained between 2000 and 2002 as part of two nested case-control studies, one with cases of incident cardiovascular disease and the other with cases of carotid plaque progression by ultrasound. Cardiac CT examinations for the presence of CAC were performed at baseline and at two additional examinations. CAC scores (Agatston and volume) and density scores (for those with positive CAC) were calculated. Multivariable linear regression modeling per SD increment of CMEC was used to estimate the associations of CMEC with each of these CAC measures. We found no association between higher CMEC and either lower CAC scores or a higher CAC density. We also found no association between higher CMEC and progression of any of these CAC measures. These findings suggest that HDL-mediated cholesterol efflux may be associated with cardiovascular risk via mechanisms unrelated to burden of calcified plaque.
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| http://dx.doi.org/10.1016/j.jacl.2022.09.004 | DOI Listing |
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