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Fibrinolysis resistance after liver transplant as a predictor of early infection. | LitMetric

Fibrinolysis resistance after liver transplant as a predictor of early infection.

Am J Surg

Colorado Center for Transplantation Care, Research, and Education (CCTCARE). Department of Surgery, University of Colorado Anschutz Medical Campus, 1635 Aurora Court, C-318, Aurora, CO, 80045, USA.

Published: December 2022

AI Article Synopsis

Article Abstract

Background: Infection is a leading cause of morbidity in liver transplant (LT). Considering that the fibrinolytic system is altered in sepsis, we investigated the relationship between fibrinolysis resistance (FR) and post-transplant infection.

Methods: Fibrinolysis was quantified using thrombelastography (TEG) with the addition of tPA to quantify FR. FR was defined as LY30 = 0% and stratified as transient if present on POD1 or POD5 (tFR), persistent (pFR) if present on both, or no FR (nFR) if absent.

Results: 180 LT recipients were prospectively enrolled. 52 (29%) recipients developed infection. 72 had tFR; 37 had pFR; and 71 had nFR. Recipients with pFR had significantly greater incidence of infections (51% vs. 26% tFR vs. 20% nFR, p = 0.002). pFR was independently associated with increased odds of post-transplant infection (adjusted OR 3.39, p = 0.009).

Conclusions: Persistent fibrinolysis resistance is associated with increased risk of post-transplant infection.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424327PMC
http://dx.doi.org/10.1016/j.amjsurg.2022.09.011DOI Listing

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