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Innovative laparoscopic technique for the resection of a giant abdominal cyst in a young female: A case report.
Int J Surg Case Rep
February 2025
Security Force Hospital, King Fahad Suburb, 32314 Dammam, Saudi Arabia.
Introduction: Abdominal cystic lesions are a diverse spectrum of pathologies, predominantly ovarian in origin, including benign functional cysts to malignant neoplasms. This report presents a novel laparoscopic technique for resection of large abdominal cysts with oncological safety.
Case Presentation: A 23-year-old female had a 2-year history of progressive abdominal distension.
[Analgesic effect of "Zhibian" (BL54)-toward-"Shuidao" (ST28) needling technique of acupuncture on primary dysmenorrhea based on NOD1/RIP2/NF-κB signaling pathway in the rats].
Zhongguo Zhen Jiu
February 2025
Affiliated Hospital of Acupuncture-Moxibustion and Tuina, Shanxi University of CM, Taiyuan 030012.
Objective: To observe the effect of "Zhibian" (BL54)-toward-"Shuidao" (ST28) needling technique on the relative protein expression of the signaling pathway of nucleotide-binding oligomerization domain-containing protein 1 (NOD1)/ receptor-interacting protein 2 (RIP2)/nuclear factor kappa-B (NF-κB) and the expression of proinflammatory cytokines in the rats with primary dysmenorrhea (PD), so as to explore the underlying mechanism of this acupuncture technique for pain alleviation in PD.
Methods: Thirty female SD rats of SPF grade with normal estrous cycle were randomized into a blank group, a model group and an acupuncture group, 10 rats in each one. Using the intraperitoneal injection with estradiol benzoate combined with oxytocin, PD model was prepared in the model group and the acupuncture group.
Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosis.
EBioMedicine
February 2025
Institut Pasteur, Université Paris Cité, CNRS UMR6047, INSERM U1306, Unité de Biologie et Génétique de la Paroi Bactérienne, Paris, F-75015, France. Electronic address:
Background: Leptospirosis is a globally neglected re-emerging zoonosis affecting all mammals, albeit with variable outcomes. Humans are susceptible to leptospirosis; infection with Leptospira interrogans species can cause severe disease in humans, with multi-organ failure, mainly affecting kidney, lung and liver function, leading to death in 10% of cases. Mice and rats are more resistant to acute disease and can carry leptospires asymptomatically in the kidneys and act as reservoirs, shedding leptospires into the environment.
View Article and Find Full Text PDFGinsenoside Rk1 exerts protective effects of LPS-induced podocyte apoptosis and inflammation by inactivating JAK2/STAT3 and NF-κB pathways.
Drug Chem Toxicol
December 2024
Internal Medicine Department, Shenzhen Bao'an Authentic TCM Therapy Hospital, Shenzhen, China.
Podocyte injury is a major biomarker of primary glomerular disease that leads to massive proteinuria and kidney failure. Ginsenoside Rk1, a substance derived from ginseng, has several pharmacological activities, such as anti-apoptotic, anti-inflammatory, and antioxidant effects. In this study, our goal is to investigate the roles and mechanisms of ginsenoside Rk1 in podocyte injury and acute kidney injury (AKI).
View Article and Find Full Text PDFNeuroprotective Potential of Ethoxzolamide Targeting Oxidative Stress and Inflammation in Experimental Models of Intracerebral Hemorrhage.
Front Biosci (Landmark Ed)
October 2024
Department of Neurosurgery, Minhang Hospital, Fudan University, 201100 Shanghai, China.
Article Synopsis
- Carbonic anhydrase inhibitors like ethoxyzolamide (ETZ) may have therapeutic benefits for central nervous system trauma, specifically intracerebral hemorrhage (ICH), but its effectiveness is still under investigation.
- Experiments using ICH models showed that ETZ improves neuronal damage and reduces inflammation and oxidative stress markers in a dose-dependent manner, while also maintaining liver and kidney function.
- The study suggests that ETZ activates the Keap1/Nrf2 pathway, enhancing antioxidant effects, by binding to the Nrf2 domain in cells affected by ICH.
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