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Imaging biomarkers of cortical neurodegeneration underlying cognitive impairment in Parkinson's disease.
Eur J Nucl Med Mol Imaging
January 2025
Reina Sofia Alzheimer Center, CIEN Foundation, ISCIII, Madrid, Spain.
Purpose: Imaging biomarkers bear great promise for improving the diagnosis and prognosis of cognitive impairment in Parkinson's disease (PD). We compared the ability of three commonly used neuroimaging modalities to detect cortical changes in PD patients with mild cognitive impairment (PD-MCI) and dementia (PDD).
Methods: 53 cognitively normal PD patients (PD-CN), 32 PD-MCI, and 35 PDD underwent concurrent structural MRI (sMRI), diffusion-weighted MRI (dMRI), and [F]FDG PET.
Assessing the Correlation Between Langerhans Cells Population and Prognosis of Tongue Squamous Cell Carcinoma.
Clin Exp Dent Res
February 2025
School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Background And Objective: Tongue squamous cell carcinoma (TSCC) is the most prevalent oral cancer. Despite considerable advancements in treatment, the 5-year survival rate remains relatively unchanged. Langerhans cells (LCs) play an important role in antitumor immunity.
View Article and Find Full Text PDF"Cell dedifferentiation" versus "evolutionary reversal" theories of cancer: The direct contest of transcriptomic features.
Int J Cancer
January 2025
Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
Cell dedifferentiation is considered an important hallmark of cancer. The atavistic reversal to a unicellular-like (UC) state is a less widely accepted concept, so far not included in the conventional hallmarks. The activated expression of ontogenetically earlier and evolutionary earlier genes in cancers supports both theories because ontogenesis partially recapitulates phylogenesis during cell differentiation (the cellular biogenetic law).
View Article and Find Full Text PDFA Perspective on Lung Cancer and Lung Microbiome: Insight on Immunity.
Immun Inflamm Dis
February 2025
Department of Medical Laboratory Sciences, Faculty of Medical Sciences, Islamic Azad University, Arak Branch, Arak, Iran.
Background: Although the carcinogenic potential of microbes has long been recognized, their significance may have been underestimated. Currently, the connection between microbiota and cancer is under extensive research. The lung microbiota may serve as a proxy for the state of lung health based on its crucial role in preserving lung hemostasis.
View Article and Find Full Text PDFMeta-analysis of randomized controlled trials of external-beam radiation versus transarterial chemoembolization for hepatocellular carcinoma.
Cancer
February 2025
Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Background: External-beam radiation (EBRT) is a noninvasive therapeutic alternative to transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). The objective of this study was to conduct a systematic review and meta-analysis of prospective randomized clinical trials to assess the clinical efficacy of EBRT versus TACE for HCC as either a definitive monotherapy or as a bridge to transplantation/surgery.
Methods: A systematic review and meta-analysis were performed to include prospective randomized trials comparing EBRT versus TACE.
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