We report herein a new method for the synthesis of densely functionalized chiral allyl SCF , SCF R, SCN and SAr species with a separate CF functionality. The synthetic approach is based on selenium-catalyzed sulfenofunctionalization of chiral α-CF allylboronic acids. The reactions proceeded with remarkably high stereo-, diastereo- and site-selectivity, based on the formation of a stable thiiranium ion followed by rapid deborylative ring opening.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828052 | PMC |
| http://dx.doi.org/10.1002/anie.202210509 | DOI Listing |
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