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Prospective Study of Corneal Sensitivity in Patients Treated With Proton Therapy for Extraocular Tumors.
Cornea
December 2024
Centre Hospitalier Universitaire de Caen-Normandie, Service d'Ophtalmologie, Unicaen-Universite de Caen Normandie, Caen, France.
Introduction: Several cases of radio-induced neurotrophic keratitis had been observed after proton therapy delivering a mean corneal dose of ≥50 GyRBE. We conducted a prospective exploratory study to assess corneal sensitivity in subsequent patients undergoing proton therapy for cephalic extraocular tumors.
Material And Methods: Forty-three patients (85 eyes) treated with high-energy proton therapy were included in this prospective, single-center, observational cohort study.
Umbilical Cord Blood-Derived Products in Autoimmune Systemic Syndromes with Severe Dryness: A Pilot Study.
Medicina (Kaunas)
October 2024
Department of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.
Article Synopsis
- Human umbilical cord blood serum (HUCBS) shows promise as an effective treatment for severe ocular surface disorders (OSDs) by speeding up healing and reducing inflammation, benefiting patients who haven't found relief through standard therapies.
- A study of 49 patients with various severe OSDs was conducted at San Marco Hospital in Italy, categorizing patients based on causes like rheumatologic diseases and graft-versus-host disease.
- Results indicated significant improvement in multiple assessments, including patient-reported outcomes and clinical evaluations, demonstrating the potential of HUCBS in treating resistant cases of OSDs.
Neuronal Intranuclear Inclusion Disease with a Corneal Disorder: A Case Report.
Medicina (Kaunas)
October 2024
Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki City 852-8501, Japan.
: Neuronal intranuclear inclusion disease (NIID) is a progressive neurodegenerative disorder characterized by the formation of intranuclear inclusions in cells. Adult-type NIID usually develops in elderly patients with various clinical manifestations and is sometimes accompanied by ocular symptoms. A case of adult-onset NIID with early and unique manifestations, including a progressive corneal defect and retinal changes, which are concerning at a young age, is reported.
View Article and Find Full Text PDFTopical Insulin for Neurotrophic-Related Epithelial Defects: Where do We Stand? A Systematic Review.
J Curr Ophthalmol
October 2024
Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium.
Purpose: To review the existing literature to evaluate the utility of insulin eye drops as a treatment for neurotrophic-related epithelial defects.
Methods: A comprehensive literature search of Medline, Embase, and Web of Science and additional manual searches were conducted using relevant keywords. All articles published from January 2005 to January 2024 were examined.
Nerve Growth Factor Treatment for Neurotrophic Keratopathy in IRIS® Registry.
Ophthalmology
November 2024
Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Nerve growth factor treatment significantly improved visual acuity and non-visual outcomes and reversed the trend of visual decline in 1,476 patients with neurotrophic keratopathy within the IRIS Registry.
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