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Toxicological effects of long-term continuous exposure to ambient air on human bronchial epithelial Calu-3 cells exposed at the air-liquid interface.
Environ Res
January 2025
Joint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics (CMA), Helmholtz Zentrum München, Munich, 85764, Germany; Joint Mass Spectrometry Center (JMSC) at Analytical Chemistry, Institute of Chemistry, University of Rostock, Rostock, 18051, Germany.
Air pollution significantly contributes to the global burden of respiratory and cardiovascular diseases. While single source/compound studies dominate current research, long-term, multi-pollutant studies are crucial to understanding the health impacts of environmental aerosols. Our study aimed to use the first air-liquid interface (ALI) aerosol exposure system adapted for long-term in vitro exposures for ambient air in vitro exposure.
View Article and Find Full Text PDFImproving agricultural spraying with multi-rotor drones: a technical study on operational parameter optimization.
Front Nutr
December 2024
Directorate of Crop Management, Tamil Nadu Agricultural University, Coimbatore, India.
Article Synopsis
- Drones are improving nutrient management by allowing precise spraying techniques, which are especially important under climate change.
- Current research focuses on optimizing various parameters like flight height, pressure, and nozzle configuration to enhance spray efficiency and reduce waste.
- The study found that a hover height of 2.0 meters provided the best spray uniformity and distribution, showing the effectiveness of careful drone operation in agricultural practices.
miRNAome-metabolome wide association study reveals effects of miRNA regulation in eosinophilia and airflow obstruction in childhood asthma.
EBioMedicine
December 2024
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:
Background: There are important inter-relationships between miRNAs and metabolites: alterations in miRNA expression can be induced by various metabolic stimuli, and miRNAs play a regulatory role in numerous cellular processes, impacting metabolism. While both specific miRNAs and metabolites have been identified for their role in childhood asthma, there has been no global assessment of the combined effect of miRNAs and the metabolome in childhood asthma.
Methods: We performed miRNAome-metabolome-wide association studies ('miR-metabo-WAS') in two childhood cohorts of asthma to evaluate the contemporaneous and persistent miRNA-metabolite associations: 1) Genetic Epidemiology of Asthma in Costa Rica Study (GACRS) (N = 1121); 2) the Childhood Asthma Management Program (CAMP) (N = 312 and N = 454).
The Effects of Different Hygiene Instrumentations on Titanium Implant Fixture Surfaces.
Cureus
November 2024
School of Dental Sciences, Universiti Sains Malaysia, Kota Bharu, MYS.
Background and objective Applying different hygiene tools for implant maintenance alters surface configurations, impacting bacterial adhesion on titanium implant surfaces and potentially leading to peri-implant diseases. This study aimed to assess the alterations in surface topography of titanium implant fixtures after utilizing hygiene instruments such as airflow; erbium, chromium-doped: yttrium, scandium, gallium, and garnet (Er, Cr: YSGG) laser; and titanium brush, under scanning electron microscope (SEM) observation. Materials and methods We employed an experimental laboratory study design for this research, involving 20 MegaGen ST titanium implant fixtures (MegaGen Implant Co.
View Article and Find Full Text PDFCorrelation of Two-Minute and Six-Minute Walk Tests With Spirometric Indices in Patients With Severe Chronic Obstructive Pulmonary Disease at a Selected Tertiary Care Hospital in Puducherry.
Cureus
November 2024
Pulmonary Medicine, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, IND.
Background Chronic obstructive pulmonary disease (COPD) is a progressive respiratory condition characterised by airflow limitation and reduced exercise capacity. The Six-Minute Walk Test (6MWT) and Two-Minute Walk Test (2MWT) are commonly used to assess functional exercise capacity in COPD patients. This study aims to evaluate the correlation between the distance covered in the 2MWT and 6MWT with spirometric indices (such as Forced Expiratory Volume in 1 second (FEV₁), Forced Vital Capacity (FVC), and FEV₁/FVC) in COPD patients.
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