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Vessel invasion is a risk factor for gastric cancer: a retrospective analysis study.
World J Surg Oncol
December 2024
Department of Gastrointestinal Surgery, Navy Medical University First Affiliated Hospital, Shanghai, China.
Objective: To explore the relationship between vessel invasion (VI) and clinicopathological features and prognosis in patients with gastric cancer (GC).
Methods: A total of 3600 cases of patients with GC who underwent radical gastrectomy in gastrointestinal surgery department of the First Affiliated Hospital of Naval Medical University from June 2014 to June 2019 were retrospectively analyzed, and filtering them based on specific inclusion and exclusion criteria. To reduce the possibility of selection bias about the impact of VI, patients were divided into two groups according to the presence or absence of it, and performed a one-to-one propensity score matching (PSM), resulting in 724 patients in each group.
Detection of a novel DNA methylation marker panel for esophageal cancer diagnosis using circulating tumor DNA.
BMC Cancer
December 2024
Department of Molecular Pathology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, No 127, Dongming Road, Zhengzhou, 450008, Henan, China.
Background: Esophageal cancer (ECa) is one of the most deadly cancers, with increasing incidence worldwide and poor prognosis. While endoscopy is recommended for the detection of ECa in high-risk individuals, it is not suitable for large-scale screening due to its invasiveness and inconvenience.
Methods: In this study, a novel gene methylation panel was developed for a blood-based test, and its diagnostic efficacy was evaluated using a cohort of 304 participants (203 cases, 101 controls).
Association between exposure to gender and sexual diversity in media (GSDM) and Thai adolescents' attitude towards LGBT individuals: a cross-sectional study in Bangkok schools.
BMJ Open
December 2024
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Objective: In recent years, global media has increasingly represented lesbian, gay, bisexual and transgender (LGBT) individuals, contributing to greater societal acceptance of diverse sexualities and gender identities. However, in Thailand, negative attitudes towards LGBT individuals remain prevalent, and media portrayals, both positive and negative, play a critical role in shaping public perceptions. These portrayals can significantly influence how different groups, particularly adolescents, view LGBT individuals.
View Article and Find Full Text PDFPrevalence of detransition in persons seeking gender-affirming hormonal treatments: a systematic review.
J Sex Med
December 2024
Centre Universitaire d'Enseignement par Simulation-CUESim, Virtual Hospital of Lorraine, Faculty of Medicine, Midwifery and Health Professions, Université de Lorraine, 9, Avenue de la Forêt de Haye, Vandoeuvre-lès-Nancy, 54505, France.
Background: Despite recent evidence of the benefits of gender-affirming medical procedures, data in the literature indicate emerging demands of detransition and regrets while suggesting potential sources of bias in different datasets, including a nonconsensual definition of detransition.
Aim: The present systematic review aims to summarize the existing research regarding the prevalence of detransition in transgender persons who requested or started receiving gonadotrophin-releasing hormone analogs (GnRHa) and/or gender-affirming hormonal therapy (GAHT).
Methods: A systematic literature search (CINAHL Plus, Cochrane Library, Google Scholar, MEDLINE, Web of Science, Sage Journals, Science Direct, Scopus) for quantitative studies was conducted up to May 2024.
Background: This study addresses the intricate landscape of racial disparities in healthcare delivery, with a specific focus on surgical procedures. The concern was accentuated by the challenges posed during the COVID-19 pandemic when resources became scarce. Recognizing the potential impact of provider bias in medical decision-making, the American College of Surgeons introduced the Medically Necessary and Time-Sensitive (MeNTS) scoring system.
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