Introduction: Further evidence is needed to support the use of plasma amyloid β (Aβ) biomarkers as Alzheimer's disease prescreening tools. This study evaluated the clinical performance and robustness of plasma Aβ /Aβ for amyloid positivity prescreening.

Methods: Data were collected from 333 BioFINDER and 121 Alzheimer's Disease Neuroimaging Initiative study participants. Risk and predictive values versus percentile of plasma Aβ /Aβ evaluated the actionability of plasma Aβ /Aβ , and simulations modeled the impact of potential uncertainties and biases. Amyloid PET was the brain amyloidosis reference standard.

Results: Elecsys plasma Aβ /Aβ could potentially rule out amyloid pathology in populations with low-to-moderate amyloid positivity prevalence. However, simulations showed small measurement or pre-analytical errors in Aβ and/or Aβ cause misclassifications, impacting sensitivity or specificity. The minor fold change between amyloid PET positive and negative cases explains the biomarkers low robustness.

Discussion: Implementing plasma Aβ /Aβ for routine clinical use may pose significant challenges, with misclassification risks.

Highlights: Plasma Aβ /Aβ ruled out amyloid PET positivity in a setting of low amyloid-positive prevalence. Including (pre-) analytical errors or measurement biases caused misclassifications. Plasma Aβ /Aβ had a low inherent dynamic range, independent of analytical method. Other blood biomarkers may be easier to implement as robust prescreening tools.

Download full-text PDF

Source
http://dx.doi.org/10.1002/alz.12801DOI Listing

Publication Analysis

Top Keywords

plasma aβ
28
aβ /aβ
28
amyloid pet
12
10
plasma
9
clinical performance
8
performance robustness
8
alzheimer's disease
8
prescreening tools
8
amyloid positivity
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!