N- and O-arylated compounds are prevalent in pharmaceuticals and materials, and efficient approaches for their synthesis are important. Herein, we present an efficient protocol for the diarylation of aliphatic amines and water with two structurally different aryl groups in one single step, yielding highly functionalized diaryl amines and ethers. We describe the synthesis of the required diaryliodonium salts and detail the procedure for the diarylation. The protocol is limited to use of unhindered amines and diaryliodonium salts with certain substituents. For complete details on the use and execution of this protocol, please refer to Linde et al. (2022).
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| http://dx.doi.org/10.1016/j.xpro.2022.101700 | DOI Listing |
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