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Expanding generalized contrast-to-noise ratio into a clinically relevant measure of lesion detectability by considering size and spatial resolution.
J Med Imaging (Bellingham)
September 2024
Vanderbilt University, Nashville, Tennessee, United States.
Purpose: Early image quality metrics were often designed with clinicians in mind, and ideal metrics would correlate with the subjective opinion of practitioners. Over time, adaptive beamformers and other post-processing methods have become more common, and these newer methods often violate assumptions of earlier image quality metrics, invalidating the meaning of those metrics. The result is that beamformers may "manipulate" metrics without producing more clinical information.
View Article and Find Full Text PDFPrescription trends in Japanese advanced Parkinson's disease patients with non-motor symptoms: J-FIRST.
PLoS One
October 2024
Division of Biostatistics, Tohoku University Graduate School of Medicine, Miyagi, Japan.
Background: Non-motor symptoms (NMS) are important factors when selecting treatments for patients with advanced Parkinson's disease (PD). We sought to elucidate the prescribing practices for advanced PD patients with NMS in Japanese clinical practice.
Methods: We examined the prescription rates and doses of anti-PD drugs, and the use of non-steroidal anti-inflammatory drugs (NSAIDs) in post hoc analyses of a 52-week observational study of 996 PD patients with wearing-off on levodopa-containing therapy and ≥1 NMS.
TB prevention and immunization in pediatrics.
Indian J Tuberc
October 2024
Topiwala National Medical College, Mumbai, 400008, India. Electronic address:
Tuberculosis (TB) is one of the main contributors to global mortality and morbidity. Prevalence of TB is more in developing countries. It is one of the airborne diseases that has always been a major health problem.
View Article and Find Full Text PDFAyurveda therapy in the management of epilepsy.
Epilepsy Behav
October 2024
Centre for Molecular Neurosciences, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, India. Electronic address:
Epilepsy, a chronic non-communicable disease of the brain, is one of the most common neurological diseases globally that affects people of all ages. The existence of medical, neurological, psychiatric, and cognitive comorbidities has always undermined the available advanced treatment strategies for epilepsy. New-generation antiepileptic drugs being less successful in completely controlling the seizures and observance of complex diseases, including drug-resistant cases, have provided scope for integrating and incorporating the therapeutic modalities of Ayurveda, the ancient Indian art of holistic medicine, in the effective management of epilepsy.
View Article and Find Full Text PDFLevodopa Equivalent Daily Dosage: Geographical Variations and Real-Life Modules in Parkinson's Disease.
Mov Disord Clin Pract
November 2024
Parkinson's Disease and Movement Disorders Research Center, Citi Neuro Center, Hyderabad, India.
Background: The Levodopa Equivalent Daily Dosage (LEDD) calculation algorithms help in capturing and harmonization of Parkinson's Disease (PD) therapies. Analyzing these updates is essential for validating their effectiveness.
Objective: To assess updated LEDD conversion factors in capturing the newer therapies in PD and therapy modules in different geographical cohorts.
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