We report Mycetohabitans rhizoxinica bacteremia in a 65-year-old woman in California, USA, who was undergoing chimeric antigen receptor T-cell therapy for multiple myeloma. Acute brain infarction and pneumonia developed; Rhizopus microsporus mold was isolated from tracheal suction. Whole-genome sequencing confirmed bacteria in blood as genetically identical to endofungal bacteria inside the mold.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514336PMC
http://dx.doi.org/10.3201/eid2810.220507DOI Listing

Publication Analysis

Top Keywords

mycetohabitans rhizoxinica
8
rhizoxinica bacteremia
8
rhizopus microsporus
8
endofungal mycetohabitans
4
bacteremia associated
4
associated rhizopus
4
microsporus respiratory
4
respiratory tract
4
tract infection
4
infection report
4

Similar Publications

Endosymbioses have profoundly impacted the evolution of life and continue to shape the ecology of a wide range of species. They give rise to new combinations of biochemical capabilities that promote innovation and diversification. Despite the many examples of known endosymbioses across the tree of life, their de novo emergence is rare and challenging to uncover in retrospect.

View Article and Find Full Text PDF

Prevalence and diversity of TAL effector-like proteins in fungal endosymbiotic spp.

Microb Genom

June 2024

Plant Pathology and Plant-Microbe Biology, School of Integrative Plant Science, Cornell University, Ithaca, NY 14850, USA.

Endofungal (formerly ) spp. rely on a type III secretion system to deliver mostly unidentified effector proteins when colonizing their host fungus, . The one known secreted effector family from consists of homologues of transcription activator-like (TAL) effectors, which are used by plant pathogenic and spp.

View Article and Find Full Text PDF

The endosymbiosis between the pathogenic fungus Rhizopus microsporus and the toxin-producing bacterium Mycetohabitans rhizoxinica represents a unique example of host control by an endosymbiont. Fungal sporulation strictly depends on the presence of endosymbionts as well as bacterially produced secondary metabolites. However, an influence of primary metabolites on host control remained unexplored.

View Article and Find Full Text PDF

Transcription activator-like effector protects bacterial endosymbionts from entrapment within fungal hyphae.

Curr Biol

July 2023

Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11a, 07745 Jena, Germany; Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, 07743 Jena, Germany. Electronic address:

As an endosymbiont of the ecologically and medically relevant fungus Rhizopus microsporus, the toxin-producing bacterium Mycetohabitans rhizoxinica faces myriad challenges, such as evading the host's defense mechanisms. However, the bacterial effector(s) that facilitate the remarkable ability of M. rhizoxinica to freely migrate within fungal hyphae have thus far remained unknown.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!