We report Mycetohabitans rhizoxinica bacteremia in a 65-year-old woman in California, USA, who was undergoing chimeric antigen receptor T-cell therapy for multiple myeloma. Acute brain infarction and pneumonia developed; Rhizopus microsporus mold was isolated from tracheal suction. Whole-genome sequencing confirmed bacteria in blood as genetically identical to endofungal bacteria inside the mold.
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http://dx.doi.org/10.3201/eid2810.220507 | DOI Listing |
Nature
November 2024
Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland.
Endosymbioses have profoundly impacted the evolution of life and continue to shape the ecology of a wide range of species. They give rise to new combinations of biochemical capabilities that promote innovation and diversification. Despite the many examples of known endosymbioses across the tree of life, their de novo emergence is rare and challenging to uncover in retrospect.
View Article and Find Full Text PDFMicrob Genom
June 2024
Plant Pathology and Plant-Microbe Biology, School of Integrative Plant Science, Cornell University, Ithaca, NY 14850, USA.
Endofungal (formerly ) spp. rely on a type III secretion system to deliver mostly unidentified effector proteins when colonizing their host fungus, . The one known secreted effector family from consists of homologues of transcription activator-like (TAL) effectors, which are used by plant pathogenic and spp.
View Article and Find Full Text PDFISME J
January 2024
Junior Research Group Synthetic Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI), 07745 Jena, Thuringia, Germany.
The endosymbiosis between the pathogenic fungus Rhizopus microsporus and the toxin-producing bacterium Mycetohabitans rhizoxinica represents a unique example of host control by an endosymbiont. Fungal sporulation strictly depends on the presence of endosymbionts as well as bacterially produced secondary metabolites. However, an influence of primary metabolites on host control remained unexplored.
View Article and Find Full Text PDFCurr Biol
July 2023
Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11a, 07745 Jena, Germany; Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, 07743 Jena, Germany. Electronic address:
As an endosymbiont of the ecologically and medically relevant fungus Rhizopus microsporus, the toxin-producing bacterium Mycetohabitans rhizoxinica faces myriad challenges, such as evading the host's defense mechanisms. However, the bacterial effector(s) that facilitate the remarkable ability of M. rhizoxinica to freely migrate within fungal hyphae have thus far remained unknown.
View Article and Find Full Text PDFMycopathologia
April 2023
Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, 1959 NE Pacific Street, Box 357110, Seattle, WA, 98118, USA.
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