Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring.

Analyst

School of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, East China Normal University, Shanghai 200241, China.

Published: October 2022

Herein, we report a portable point-of-care testing (POCT) device based on an aptamer-engineered extended-gate field-effect transistor (EG-FET) for therapeutic monitoring of the drug methotrexate. This method was shown to be highly sensitive, efficient, and convenient to use, features contributing to its realizing a clinical detection of drugs in blood.

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Source
http://dx.doi.org/10.1039/d2an01393bDOI Listing

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