Morphological changes occurring in the rabbit retina after fast neutron irradiation levels of 250,500 and 1,000 cGy are discussed. The threshold dose that may cause damage to retinal structures is 250 cGy.

Download full-text PDF

Source
http://dx.doi.org/10.1159/000265477DOI Listing

Publication Analysis

Top Keywords

ultrastructural retinal
4
retinal changes
4
changes irradiation
4
irradiation fast
4
fast neutrons
4
neutrons morphological
4
morphological changes
4
changes occurring
4
occurring rabbit
4
rabbit retina
4

Similar Publications

Direction selectivity is a fundamental feature in the visual system. In the retina, direction selectivity is independently computed by ON and OFF circuits. However, the advantages of extracting directional information from these two independent circuits are unclear.

View Article and Find Full Text PDF

Early ultrastructural damage in retina and optic nerve following intraocular pressure elevation.

Vision Res

January 2025

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Elevated intraocular pressure (IOP) is a significant risk factor for glaucoma, causing structural and functional damage to the eye. Increased IOP compromises the metabolic and structural integrity of retinal ganglion cell (RGC) axons, leading to progressive degeneration and influencing the ocular immune response. This study investigated early cellular and molecular changes in the retina and optic nerve (ON) following ocular hypertension (OHT).

View Article and Find Full Text PDF

Rod and cone photoreceptor cells are specialized neurons responsible for transforming the information reaching the eyes in the form of photons into the language of neuronal activity. Rods are the most prevalent photoreceptor type, primarily responsible for light detection under conditions of limited illumination. Here we demonstrate that human rods have a morphological organization unique among all described species, whereby the cell soma extends alongside the light-sensitive outer segment compartment to form a structure we have termed the "accessory inner segment.

View Article and Find Full Text PDF

Purpose: The retinal pigment epithelium (RPE) plays an important role in the pathogenesis of age-related macular degeneration (AMD) and other retinal degenerative diseases. The introduction of healthy RPE cell cultures into the subretinal space offers a potential treatment strategy. The aim of this study was the long-term culture and characterisation of RPE cells on nanofiber scaffolds.

View Article and Find Full Text PDF

Role of Mutyh in Oxidative Stress Damage in Retinopathy of Prematurity.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao

December 2024

Department of Neonatology, Children's Hospital of Nanjing Medical University,Nanjing 210000,China.

Objective To explore the role of the base mismatch repair gene Mutyh in retinopathy of prematurity(ROP). Methods Mutyh(-/-)and wild-type(WT)mice were used for the modeling of oxygen-induced retinopathy.The retinal oxidative stress was examined,and the ultrastructures of photoreceptors and mitochondria were observed.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!