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| http://dx.doi.org/10.1016/j.jdcr.2022.03.026 | DOI Listing |
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Uncommon and Unusual Variants of Autoimmune Bullous Diseases.
Indian Dermatol Online J
August 2024
Department of Dermatology, Venereology and Leprology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Article Synopsis
- Autoimmune blistering diseases (AIBDs) are skin conditions caused by the body's immune system attacking certain proteins, leading to blister formation, and can be categorized into intraepidermal and subepidermal types.
- The objective of this review is to raise awareness about rare and uncommon AIBD variants, such as pemphigus herpetiformis and anti-laminin 332 pemphigoid, among others.
- By discussing these unusual variants, the review aims to assist healthcare professionals in the early diagnosis and treatment of these conditions.
Diagnosis of autoimmune bullous dermatoses: Comparative analysis of immunohistochemical staining using C4d, C3d, IgG, and IgG4 in lesional tissues and perilesional frozen skin samples.
Ann Diagn Pathol
December 2024
Tekirdağ Namık Kemal University Medical Faculty, Dermatology and Venereology Department, Tekirdağ, Turkey. Electronic address:
Article Synopsis
- Immunohistochemical staining using immunoglobulins and complements can help diagnose autoimmune bullous dermatoses (AIBD), particularly when combined with clinical and histological assessments.
- A study analyzed 136 biopsy cases suspected of AIBD over four years, confirming diagnoses through various methods, with 52 ultimately classified as AIBD.
- In lesional biopsies, certain markers (C4d, C3d, IgG, and IgG4) showed varying sensitivity and specificity for identifying pemphigoid and pemphigus diseases, with particularly high specificity noted in pemphigoid cases.
Direct immunofluorescence (DIF) versus immunohistochemical (IHC) staining of complements and immunoglobulins (Ig) in pemphigus group.
Indian J Pathol Microbiol
April 2024
Department of Dermatology, Maulana Azad Medical College, New Delhi, Delhi, India.
Article Synopsis
- Pemphigus is a skin disorder caused by autoantibodies affecting the epidermis, making diagnosis difficult due to the complex requirements of techniques like Direct Immunofluorescence (DIF).
- The study aimed to assess the effectiveness of immunohistochemical (IHC) staining for immunoglobulin and complement in diagnosing different types of pemphigus.
- Results indicated that IHC staining showed high positivity rates for various markers (particularly IgG and C3), suggesting it could be a viable alternative to DIF for diagnosing pemphigus, especially pemphigus vulgaris (PV).
Classification and Antigen Molecules of Autoimmune Bullous Diseases.
Biomolecules
April 2023
Department of Laboratory Medicine, Medical College, Dalian University, Dalian 116622, China.
Autoimmune bullous diseases (AIBDs), which are a group of tissue-specific autoimmune diseases of the skin, present with various blistering lesions on the skin and mucous membranes, and show autoantibodies of IgG, IgA and IgM against epidermal cell surfaces and basement membrane zone. To date, AIBDs have been classified into a number of distinct subtypes by clinical and histopathological findings, and immunological characteristics. In addition, various biochemical and molecular biological studies have identified various novel autoantigens in AIBDs, which has resulted in proposals of new subtypes of AIBDs.
View Article and Find Full Text PDFIgG/IgA pemphigus with differing regional presentations.
JAAD Case Rep
October 2022
Social Hygiene Service, Public Health Services Branch, Department of Health, The Government of Hong Kong Special Administrative Region, Hong Kong.
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