AI Article Synopsis
- Transcranial ultrasound stimulation (TUS) is a safe, non-invasive brain stimulation technique aimed at improving hand reaction times and cortical excitability in healthy adults.
- In a study with 20 participants, researchers used a double-blind design where each subject received TUS and sham stimulation on different days, measuring their finger tapping performance and motor evoked potentials (MEP).
- Results showed that TUS significantly improved finger tapping scores and MEP amplitudes, while discomfort levels were similar between TUS and sham conditions, indicating TUS enhances motor function without causing discomfort.
Article Abstract
Objective: Transcranial ultrasound stimulation (TUS) is a new form of non-invasive brain stimulation. Low-intensity TUS is considered highly safe. We aimed to investigate the effect of low-intensity TUS on hand reaction responses and cortical excitability in healthy adults.
Methods: This study used a crossover, randomized, and double-blind design. A total of 20 healthy participants were recruited for the study. All the participants received TUS and sham stimulation on separate days in random order. The finger tapping test (tapping score by using a tablet) and motor evoked potential (MEP) were assessed before and after stimulation, and discomfort levels were assessed using a visual analog scale (VAS) score.
Results: No significant differences in tapping score or MEP amplitude between the two experimental conditions were registered before stimulation. After stimulation, tapping scores were increased regardless of the specific treatment, and the real stimulation condition receiving TUS (90.4 ± 11.0 points) outperformed the sham stimulation condition (86.1 ± 8.4 points) ( = 0.002). The MEP latency of real TUS (21.85 ± 1.33 ms) was shorter than that of sham TUS (22.42 ± 1.43 ms) ( < 0.001). MEP amplitude of real TUS (132.18 ± 23.28 μV) was higher than that of sham TUS (114.74 ± 25.5 μV, = 0.005). There was no significant difference in the discomfort score between the two conditions ( = 0.163).
Conclusion: Transcranial ultrasound stimulation (TUS) can decrease the hand reaction response time and latency of the MEP, enhance the excitability of the motor cortex, and improve hand motor function in healthy individuals without obvious discomfort.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486841 | PMC |
| http://dx.doi.org/10.3389/fneur.2022.926027 | DOI Listing |
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