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Poly(2,5-furandicarboxylate)s incorporating aliphatic moieties represent a promising family of polyesters, typically entirely based on renewable resources and with tailored properties, notably degradability. This study aims to go beyond by developing poly(isosorbide 2,5-furandicarboxylate--dodecanedioate) copolyesters derived from isosorbide (Is), 2,5-furandicarboxylic acid (FDCA), and 1,12-dodecanedioic acid (DDA), and studying their degradation under environmental conditions, often overlooked, namely seawater conditions. These novel polyesters have been characterized in-depth using ATR-FTIR, H, and C NMR and XRD spectroscopies and thermal analysis (TGA and DSC). They showed enhanced thermal stability (up to 330 °C), and the glass transition temperature increased with the content of FDCA from ca. 9 to 60 °C. Regarding their (bio)degradation, the enzymatic conditions lead to the highest weight loss compared to simulated seawater conditions, with values matching 27% vs. 3% weight loss after 63 days of incubation, respectively. Copolymerization of biobased FDCA, Is, and DDA represents an optimal approach for shaping the thermal/(bio)degradation behaviors of these novel polyesters.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502350 | PMC |
http://dx.doi.org/10.3390/polym14183868 | DOI Listing |
J Med Chem
December 2024
Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
A series of hypoxia-targeted nitric oxide donor compounds were designed and synthesized by using an ether linker to connect -methyl--nitroso--phenol and nitrobenzyl alcohols, respectively. Among them, , with acceptable pharmacokinetic parameters in mice, exhibited a high selective NO release in H9c2 cells under hypoxia and in the dissected heart tissue of the tested mice as desired. Mechanistic investigations revealed that could regulate vascular dilation and modulate proteins associated with myocardial injury both and .
View Article and Find Full Text PDFACS Polym Au
December 2024
Institute of Materials Chemistry, Faculty of Chemistry, Brno University of Technology, 61200 Brno, Czech Republic.
Coating materials involving nature-inspired compounds or renewable sources have recently attracted vast attention. This article presents the synthesis of modified rapeseed oil (MRO) as a precursor possessing high biobased carbon content suitable for cured thermosets formation. Two reactive diluents based on renewable sources, methacrylated methyl 3-hydroxybutyrate (M3HBMMA) and ethyl 3-hydroxybutyrate (E3HBMMA), were successfully synthesized.
View Article and Find Full Text PDFEur J Clin Pharmacol
December 2024
Maliba Pharmacy College, Uka Tarsadia University Bardoli, Dist. Surat- 394350, Gujarat, India.
Adverse drug reactions (ADRs) in elderly patients are frequently attributed to age-related altered pharmacokinetics and the complexities of polypharmacy to manage multiple chronic conditions, making elderly patients more susceptible to ADRs. The following is a case report of an 80-year-old female patient with systemic symptoms of chest pain, low blood sugar, mouth ulcers, and concentrates on peripheral edema due to nitrate vasodilator isosorbide mononitrate (ISMN). She had hypertension, diabetes, ischemic heart disease, and chronic obstructive pulmonary disease (COPD).
View Article and Find Full Text PDFEur J Case Rep Intern Med
November 2024
Faculty of Medicine, Damascus University, Damascus, Syria.
Unlabelled: Hyperlipidaemia is considered one of the most common risk factors for ischemic heart disease. Severely elevated triglyceride levels may lead to hyperviscosity which may contribute to endothelial dysfunction, tissue ischemia and chylomicronaemia. This case report features a 39-year-old, non-smoker male with a past medical history of hypertension and no family history of coronary artery disease, who presented to the clinic with angina.
View Article and Find Full Text PDFChin Herb Med
October 2024
Department of Pharmacy, Medical Supplies Center, PLA General Hospital, Beijing 100853, China.
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