AI Article Synopsis

  • - Human African Trypanosomiasis (HAT), caused by trypanosome parasites, poses a serious health threat in sub-Saharan Africa but remains a neglected tropical disease, affecting numerous individuals, particularly in Gabon.
  • - A study in Gabon revealed that 19.34% of domestic animals tested were infected with trypanosomes, with varying rates among dogs (23.21%), goats (16.10%), and sheep (21.00%).
  • - Molecular analysis identified at least six species of trypanosomes in domestic animals, suggesting these animals may serve as significant reservoirs for the parasites linked to HAT, emphasizing the need for further research in this area.

Article Abstract

Human African Trypanosomiasis (HAT) is an infectious disease caused by protozoan parasites belonging to the genus. In sub-Saharan Africa, there is a significant threat as many people are at risk of infection. Despite this, HAT is classified as a neglected tropical disease. Over the last few years, several studies have reported the existence of a wide diversity of trypanosome species circulating in African animals. Thus, domestic and wild animals could be reservoirs of potentially dangerous trypanosomes for human populations. However, very little is known about the role of domestic animals in maintaining the transmission cycle of human trypanosomes in central Africa, especially in Gabon, where serious cases of infection are recorded each year, sometimes leading to hospitalization or death of patients. Komo-Mondah, located within Estuaries (Gabonese province), stays the most active HAT disease focus in Gabon, with a mean of 20 cases per year. In this study, we evaluated the diversity and prevalence of trypanosomes circulating in domestic animals using the Polymerase Chain Reaction (PCR) technique. We found that 19.34% (53/274) of the domestic animals we studied were infected with trypanosomes. The infection rates varied among taxa, with 23.21% (13/56) of dogs, 16.10% (19/118) of goats, and 21.00% (21/100) of sheep infected. In addition, we have observed a global mixed rate of infections of 20.75% (11/53) among infected individuals. Molecular analyses revealed that at least six species circulate in domestic animals in Gabon (, , Tsavo, , , (including , and )). In conclusion, our study showed that domestic animals constitute important potential reservoirs for trypanosome parasites, including , which is responsible for HAT.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502807PMC
http://dx.doi.org/10.3390/pathogens11090992DOI Listing

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