AI Article Synopsis
- - Acid-base homeostasis is essential for bodily functions, with the SLC4 family of HCO cotransporters playing a key role in regulating pH in cells, particularly through the NBCn1 (SLC4A7) transporter.
- - NBCn1 helps remove excess acid from cells and is involved in various processes like cell volume regulation and balancing cell death and survival.
- - The review focuses on recent findings about NBCn1, including its regulation, tissue-specific roles, and potential use of NBCn1 inhibitors in cancer treatment, advocating for further research on targeted therapies related to NBCn1.
Article Abstract
Acid-base homeostasis is critical for proper physiological function and pathology. The SLC4 family of HCO transmembrane cotransporters is one of the HCO transmembrane transport carriers responsible for cellular pH regulation and the uptake or secretion of HCO in epithelial cells. NBCn1 (SLC4A7), an electroneutral Na/HCO cotransporter, is extensively expressed in several tissues and functions as a cotransporter for net acid extrusion after cellular acidification. However, the expression and activity level of NBCn1 remain elusive. In addition, NBCn1 has been involved in numerous other cellular processes such as cell volume, cell death/survival balance, transepithelial transport, as well as regulation of cell viability. This review aims to give an inclusive overview of the most recent advances in the research of NBCn1, emphasizing the basic features, regulation, and tissue-specific physiology as well as the development and application of potent inhibitors of NBCn1 transporter in cancer therapy. Research and development of targeted therapies should be carried out for NBCn1 and its associated pathways.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505461 | PMC |
| http://dx.doi.org/10.3390/ph15091082 | DOI Listing |
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