Chemical Evaluation, and Anticancer Activity of Grown in Jordan.

Molecules

Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University, Al-Arab Str. 21, Amman 11931, Jordan.

Published: September 2022

AI Article Synopsis

  • - The study evaluates various extracts (aqueous, methanol, ethanol, ethyl acetate, and chloroform) from a widely cultivated medicinal plant, focusing on their chemical properties, antioxidant potential, and effects against breast cancer cells MCF-7 and MDA-MB-231.
  • - Among the extracts, the ethanol (EtOH) extract demonstrated the strongest cytotoxic effect, showing IC values of 104.1 µg/mL for MCF-7 and 214.5 µg/mL for MDA-MB-231 cell lines.
  • - In an in vivo experiment with mice, the ethanol extract reduced tumor size by 43.29%, while control mice showed a 58.9%

Article Abstract

is the most widely cultivated species for medicinal use. In this study, chemical and biological evaluation of aqueous, methanol (MeOH), ethanol (EtOH), ethyl acetate (EtOAc), and chloroform (CHCl) extracts were conducted. Phytochemically, the extracts' total phenol and flavonoid contents and their antioxidant potential were evaluated. Ethanol extract was analyzed by LC-MS. All extracts were screened for their antitumor potential using human breast cancer cell lines MCF-7 and MDA-MB-23. For the first time, the antiproliferative potential of the EtOH extract was tested in vivo using mice with induced breast cancer. Ethanol extract exhibited the best cytotoxicity and safety profile of the tested extracts, with IC values of 104.1 µg/mL on MCF-7 and 214.5 µg/mL on MDA-MB-231 cell lines, respectively. , this extract revealed a reduction in tumor size by 43.29% in the treated group, compared to an increase in the tumor growth by 58.9% in the control group. Moreover, undetected tumor was found in 12.5% of the sample size. In conclusion, this study provides novel insight and evidence on the antiproliferative efficacy of ethanol extract against breast cancer with potent anti-oxidant potential.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505037PMC
http://dx.doi.org/10.3390/molecules27185910DOI Listing

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