Synthesis of Novel -Trifluorothioanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity.

Molecules

Catalytic Hydrogenation Research Center, Zhejiang Key Laboratory of Green Pesticides and Cleaner Production Technology, Zhejiang Green Pesticide Collaborative Innovation Center, Zhejiang University of Technology, Hangzhou 310014, China.

Published: September 2022

AI Article Synopsis

  • Researchers designed and synthesized new herbicidal compounds containing phenylpyridine and α-trifluorothioanisole derivatives, which were confirmed using NMR and HRMS.
  • Among the tested compounds, 5a showed more than 85% effectiveness in inhibiting the growth of certain broadleaf weeds, outperforming the established herbicide fomesafen.
  • The findings indicate that compound 5a has potential for further development as a candidate herbicide for controlling a variety of broadleaf weed species.

Article Abstract

To discover novel herbicidal compounds with favorable activity, a range of phenylpyridine-moiety-containing α-trifluorothioanisole derivatives were designed, synthesized, and identified via NMR and HRMS. Preliminary screening of greenhouse-based herbicidal activity revealed that compound 5a exhibited >85% inhibitory activity against broadleaf weeds Amaranthus retroflexus, Abutilon theophrasti, and Eclipta prostrate at 37.5 g a.i./hm2, which was slightly superior to that of fomesafen. The current study suggests that compound 5a could be further optimized as an herbicide candidate to control various broadleaf weeds.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505602PMC
http://dx.doi.org/10.3390/molecules27185879DOI Listing

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