A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3098
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: Attempt to read property "Count" on bool

Filename: helpers/my_audit_helper.php

Line Number: 3100

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3100
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Enantioselective Cyclopropanation Catalyzed by Gold(I)-Carbene Complexes. | LitMetric

AI Article Synopsis

  • The study focuses on the formation of polysubstituted cyclopropanes through a gold(I)-catalyzed reaction, aiming to control the stereoselectivity for generating diverse chemical products.
  • Researchers tested various chiral gold(I)-carbene complexes and found that while they achieved high enantioselectivity, the selectivity was not influenced by the catalyst used.
  • Despite successful reactions with good yields, the enantioselectivity varied significantly, indicating that the best catalyst must be identified for each specific reagent combination due to a lack of clear structure-property relationships.

Article Abstract

The formation of polysubstituted cyclopropane derivatives in the gold(I)-catalyzed reaction of olefins and propargylic esters is a potentially useful transformation to generate diversity, therefore any method in which its stereoselectivity could be controlled is of significant interest. We prepared and tested a series of chiral gold(I)-carbene complexes as a catalyst in this transformation. With a systematic optimization of the reaction conditions, we were able to achieve high enantioselectivity in the test reaction while the selectivity of the transformation was independent of the catalyst. Using the optimized conditions, we reacted a series of various olefins and acetylene derivatives to find that, although the reactions proceeded smoothly and the products were usually isolated in good yield and with good to exclusive selectivity, the observed enantioselectivity varied greatly and was sometimes moderate at best. We were unable to establish any structure-property relationship, which suggests that for any given reagent combination, one has to identify individually the best catalyst.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501563PMC
http://dx.doi.org/10.3390/molecules27185805DOI Listing

Publication Analysis

Top Keywords

goldi-carbene complexes
8
enantioselective cyclopropanation
4
cyclopropanation catalyzed
4
catalyzed goldi-carbene
4
complexes formation
4
formation polysubstituted
4
polysubstituted cyclopropane
4
cyclopropane derivatives
4
derivatives goldi-catalyzed
4
goldi-catalyzed reaction
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!