. The aim of this study is to determine the prevailing microbiota in samples from pediatric patients with acute appendicitis, as well as evaluate the antibacterial sensitivity of the isolated microorganisms, comparing the data obtained with the clinic's antibacterial therapy guidelines. . The study group consisted of 93 patients between the ages of 7 and 18. All patients underwent a laparoscopic or conventional appendectomy. The children were hospitalized with signs and symptoms suggestive of acute appendicitis. Microbiological cultures from the appendix and abdominal cavity were collected intraoperatively. . was identified in most cases irrespective of the clinical presentation of acute appendicitis. Most strains were susceptible to ampicillin and amoxicillin/clavulanic acid. Five strains of produced extended spectrum beta-lactamase (ESBL). () was the second most commonly isolated causative agent. Furthermore, it was common in cases of acute complex appendicitis. Most strains of were resistant to amoxicillin/clavulanic acid, ertapenem, ampicillin and cefotaxime, yet were susceptible to ceftazidime. Regardless of the clinical presentation, the samples yielded mixed isolates. . is the main causative agent of acute appendicitis in the pediatric population displaying susceptibility to various antibiotics. was more prevalent in cases of acute complex appendicitis. isolates were susceptible to ceftazidime; however, they were resistant to cefotaxime, which should, therefore, be removed from guidelines for empirical antibacterial treatment of acute appendicitis due to phenotypic resistance of . We recommend antibiotics with distinct implementation to avoid antibiotic resistance.
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http://dx.doi.org/10.3390/medicina58091144 | DOI Listing |
Sci Rep
January 2025
Department of Gastrointestinal Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, No. 168 Litang Road, Changping District, Beijing, 102218, China.
The objective of this study was to develop a novel scoring model, assess its diagnostic value for complex appendicitis, and compare it with existing scoring systems. A total of 1,241 patients with acute appendicitis were included, comprising 868 patients in the modeling group (mean age, 35.6 ± 14.
View Article and Find Full Text PDFInt J Surg Case Rep
January 2025
Department of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Introduction: Amyand's hernia is a rare condition defined by the presence of the vermiform appendix within an inguinal hernia sac. The occurrence of Amyand's hernia with testicular necrosis is particularly uncommon, further complicating its clinical presentation and management.
Case Presentation: A 50-year-old male presented with a two-year history of progressive right scrotal swelling, acutely worsened over four days with pain and fever.
PLoS One
January 2025
Trauma Research, Swedish Medical Center, Englewood, Colorado, United States of America.
Previous abdominal surgery (PAS) increases risk of small bowel obstruction (SBO) due to adhesions, and appendectomy (appy) is an independent risk factor for abdominal adhesion-related complications. Peritoneal inflammation, e.g.
View Article and Find Full Text PDFScott Med J
January 2025
Department of General Surgery, University Hospital Hairmyres, NHS Lanarkshire, East Kilbride, UK.
Background: Emergency appendicectomy (EA) is a common procedure, yet few studies have focused on gender differences in these patients. This study aims to evaluate the demographics, preoperative investigations, intraoperative findings, and clinical outcomes between males and females undergoing EA.
Methods: A multicenter retrospective observational study was conducted across four hospitals involving patients who underwent EA between August 2018 and November 2025.
Diagnostics (Basel)
December 2024
1st Department of Pediatric Surgery, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Background: This specific study evaluates the accuracy of two ratios, Neutrophil-to-Lymphocyte (N/L) and Platelet-to-Lymphocyte (P/L), as inflammatory markers on differentiating simple and complicated appendicitis preoperatively.
Methods: The medical records of 341 children, up to 16 years old, with suspected acute appendicitis (AA) who underwent appendectomy, laparoscopic or open, between January 2020 and December 2022, in our department, were retrospectively reviewed. Routine blood exams and the demographic details were obtained.
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