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Association between Obstetric Complications and Intravitreal Anti-Vascular Endothelial Growth Factor Agents or Intravitreal Corticosteroids. | LitMetric

AI Article Synopsis

  • A nationwide cohort study in France examined the use of intravitreal injections (IVTs) of anti-VEGF agents and corticosteroids in pregnant women, focusing on obstetric and neonatal complications.
  • From 2009 to 2018, only 228 IVTs were given to 139 pregnant women out of over 5.6 million total IVTs performed in the country.
  • The study found a high incidence of obstetric complications among those receiving anti-VEGF (16.1% had spontaneous abortion or termination) compared to corticosteroids (3.1%), but no statistically significant link was established between the injections and these complications, highlighting the need for caution in their use during pregnancy.

Article Abstract

This nationwide population-based cohort study aimed to describe the use of intravitreal injections (IVTs) of anti-vascular endothelial growth factor (anti-VEGF) agents and corticosteroids in pregnant women in France and to report on the incidence of obstetric and neonatal complications. All pregnant women in France who received any anti-VEGF or corticosteroid IVT during pregnancy or in the month preceding pregnancy from 1 January 2009 to 31 December 2018 were identified in the national medico-administrative databases. Between 2009 and 2018, there were 5,672,921 IVTs performed in France. Among these IVTs, 228 anti-VEGF or corticosteroid IVTs were administered to 139 women during their pregnancy or in the month preceding their pregnancy. Spontaneous abortion or the medical termination of pregnancy occurred in 10 women (16.1%) who received anti-VEGF agents and in one (3.1%) of the women who received corticosteroids ( = 0.09). This is the first national cohort study of pregnant women treated with anti-VEGF or corticosteroid IVTs. We found a high incidence of obstetric complications in pregnant women treated with anti-VEGF or corticosteroid IVTs but could not demonstrate a statistically significant association between the intravitreal agents and these complications. These agents should continue to be used with great caution in pregnant women.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501719PMC
http://dx.doi.org/10.3390/jpm12091374DOI Listing

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