AI Article Synopsis
- MicroRNAs (miRNAs) are small RNAs that inhibit gene expression by binding to the 3' untranslated region of target mRNAs.
- The miR-29 family is implicated in cancer either as tumor suppressors or oncogenes, affecting crucial processes like cell growth, death, and migration.
- This review explores the role of miR-29s in cancer biology and discusses their potential use as biomarkers and therapeutic targets in human cancers.
Article Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that directly bind to the 3' untranslated region (3'-UTR) of the target mRNAs to inhibit their expression. The miRNA-29s (miR-29s) are suggested to be either tumor suppressors or oncogenic miRNAs that are strongly dysregulated in various types of cancer. Their dysregulation alters the expression of their target genes, thereby exerting influence on different cellular pathways including cell proliferation, apoptosis, migration, and invasion, thereby contributing to carcinogenesis. In the present review, we aimed to provide an overview of the current knowledge on the miR-29s biological network and its functions in cancer, as well as its current and potential applications as a diagnostic and prognostic biomarker and/or a therapeutic target in major types of human cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495592 | PMC |
| http://dx.doi.org/10.3390/biomedicines10092121 | DOI Listing |
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