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Clinical Prevalence, Antibiogram Profiling and Gompertz Growth Kinetics of Resistant Treated with Nanoparticles of Rosin Extracted from . | LitMetric

AI Article Synopsis

  • The study investigates the prevalence and antibiotic resistance patterns of methicillin-resistant Staphylococcus epidermidis (MRSE) while also assessing the effectiveness of rosin maleic anhydride nanoparticles as a treatment option.
  • Out of 200 clinical isolates, 32% showed variability in antibiotic sensitivity, with fosfomycine identified as the most effective antibiotic against MRSE.
  • Rosin maleic anhydride nanoparticles, measuring 250-350 nm, were found to inhibit MRSE growth more effectively than the control, extending the growth lag phase and suggesting a mechanism for bacterial cell disruption.

Article Abstract

The rise of methicillin-resistant (MRSE) makes it difficult to treat infections that increase morbidity and mortality rates in various parts of the world. The study's objectives include identifying the clinical prevalence, antibiogram profile, and Gompertz growth kinetics of MRSE treated with synthetically created nanoparticles of rosin obtained from . A total of 64 of 200 clinical isolates of (32% of the total) displayed sensitivity (40.62%) and resistance (59.37%) to seven different antibiotic classes. The most sensitive patterns of antibiotic resistance were seen in 20 (78.95%) and 24 (94.74%) isolates of MRSE against piperacillin/tazobactam and cephradine, respectively. Fosfomycine was found to be the most effective antibiotic against MRSE in 34 (89.47%) isolates, followed by amoxicillin. Successfully produced, described, and used against MRSE were rosin maleic anhydride nanoparticles with a size range of 250 nm to 350 nm. Five different concentrations of 25, 50, 75, 100, and 150 mg mL rosin maleic anhydride nanoparticles were investigated to treat MRSE resistance. According to Gompertz growth kinetics, the maximal growth response was 32.54% higher and the lag phase was also 10.26% longer compared to the control when the amount of rosin maleic anhydride nanoparticles was increased in the MRSE. Following the application of rosin maleic anhydride nanoparticles, the growth period is extended from 6 to 8 h. A potential mechanism for cell disintegration and distortion is put forth. This investigation came to the conclusion that rosin maleic anhydride nanoparticles better interfere with the surface of MRSE and demonstrated a preferred bacteriostatic action.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495812PMC
http://dx.doi.org/10.3390/antibiotics11091270DOI Listing

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