AI Article Synopsis
- The long noncoding RNA is often dysregulated in various cancers and has two isoforms produced by alternative 3'-end processing.
- The longer isoform is crucial for nuclear paraspeckle formation, while the shorter isoform may have a newly identified role in enhancing glycolysis, which supports cancer cell growth.
- This study shifts focus from just measuring overall expression levels to understanding how specific isoforms affect metabolism and progression in cancer.
Article Abstract
The long noncoding RNA is known to be heavily dysregulated in many cancers. A single exon gene produces two isoforms, and through alternative 3'-end processing. As the longer isoform, is an essential scaffold for nuclear paraspeckle formation. It was previously thought that the short isoform only exists to keep the locus active for rapid paraspeckle formation. However, a recent glycolysis-enhancing function for , contributing to cancer cell proliferation and the Warburg effect, has been demonstrated. Previous studies have mainly focused on quantifying total and expression levels. However, in light of the role in cancer cell metabolism, the contribution from specific isoforms is no longer clear. Here, the roles of and in metabolism and cancer progression are discussed.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497099 | PMC |
| http://dx.doi.org/10.3390/cancers14184388 | DOI Listing |
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