The Impact of Mutational Status on Long-Term Survival following Liver Resection for Hilar Cholangiocarcinoma.

mutation is reportedly associated with poor prognosis in patients with different cancer types. However, mutational data on hilar cholangiocarcinoma are few and controversial. The aim of this study was to evaluate the rate of mutations in a single-center homogeneous population resected for hilar cholangiocarcinoma and the subsequent impact on prognosis. mutation status was evaluated in 54 patients undergoing major hepatectomy combined with resection of the main biliary confluence and regional lymphadenectomy for hilar cholangiocarcinoma between 2001 and 2019. Among these 54 patients, 12 (22.2%) had a mutation. mutation was not related with pathologic characteristics of the tumor. Five-year overall survival (OS) in patients with mutation was significantly lower than that observed in patients with wild type (0 vs. 49.2%, respectively; = 0.003). In the multivariable analysis; independent predictors of poor OS were mutation (HR = 5.384; = 0.003) and lymph node metastases (HR = 2.805; = 0.023). The results of our study suggested that mutation in hilar cholangiocarcinoma was not rarely observed. mutation was an independent strong predictor of poor OS. mutation analysis should be included in the routine pathologic evaluation of resected hilar cholangiocarcinoma in order to better stratify prognosis.