AI Article Synopsis
- Fatty acids are essential for various biological functions, including maintaining cell membranes, metabolism, and signaling.
- FadL is the main protein responsible for the uptake of long-chain fatty acids in Gram-negative bacteria, with newly discovered capability to uptake fatty acids longer than 18 carbon atoms, enhancing bacterial survivability.
- In-depth molecular simulations of FadL and its homologs reveal that some have improved structural adaptations for transporting long-chain polyunsaturated fatty acids, while one homolog lacks the necessary transport channels.
Article Abstract
Fatty acids (FA) play an important role in biological functions, such as membrane homeostasis, metabolism, and as signaling molecules. FadL is the only known protein that uptakes long-chain fatty acids in Gram-negative bacteria, and this uptake has traditionally been thought to be limited to fatty acids up to 18 carbon atoms in length. Recently however, it was found has the ability to uptake fatty acids greater than 18 carbon atoms and this uptake corresponds to bacterial survivability. Using FadL as a template, FadL homologs , , and have been computationally folded, simulated on an atomistic level using Molecular Dynamics, and docked to analyze the FadL transport channels. For the and homologs, these transport channels have more structural accommodations for the many rigid unsaturated bonds of long-chain polyunsaturated fatty acids, while the homolog was found to lack transport channels within the signature beta barrel of FadL proteins.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496633 | PMC |
| http://dx.doi.org/10.3390/biom12091269 | DOI Listing |
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