Cancer continues to be an increasingly pervasive and destructive disease worldwide [...].
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http://dx.doi.org/10.3390/biom12091221 | DOI Listing |
Chem Sci
January 2025
Université de Lorraine, CNRS, IMoPA F-54000 Nancy France
The polyketide specialized metabolites of bacteria are attractive targets for generating analogues, with the goal of improving their pharmaceutical properties. Here, we aimed to produce C-26 derivatives of the giant anti-cancer stambomycin macrolides using a mutasynthesis approach, as this position has been shown previously to directly impact bioactivity. For this, we leveraged the intrinsically broad specificity of the acyl transferase domain (AT) of the modular polyketide synthase (PKS), which is responsible for the alkyl branching functionality at this position.
View Article and Find Full Text PDFJ Pharm Policy Pract
January 2025
Pharmacy Programme, Department of Health Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus.
Front Microbiol
January 2025
School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, India.
Approximately 40-50% of municipal solid waste is organic and causing biogenic malodor and infections, due to inefficient treatment methods. Biorefinery-based bioremediation and valorization is in vogue against these conventional strategies since it combines unit operations for better efficiency and productivity. Deriving inspiration, the proposed strategy puts together a unique and compatible combination of processes.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
CIC nanoGUNE, Donostia-San Sebastián 20018, Spain.
Inspired by the properties of natural chitin, the present work provides the first solid foundation for growing conformal ultrathin antibacterial films of organic chitin through a solvent-free molecular layer deposition (MLD) process. This work establishes the initial groundwork for growing biomimetic hybrid cuticles by combining sugar-type molecules with vapor-phase metal-organic precursors, which we term metallochitins or, more generally, metallosaccharides. The MLD process, featuring mild temperatures and solvent-free conditions, provides exceptional conformality and thickness precision, ensuring highly conformal coatings on diverse high aspect ratio substrates.
View Article and Find Full Text PDFACS Biomater Sci Eng
January 2025
Central Laboratory, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong 510910, China.
Myocardial infarction (MI), a severe cardiovascular condition, is typically triggered by coronary artery disease, resulting in ischemic damage and the subsequent necrosis of the myocardium. Macrophages, known for their remarkable plasticity, are capable of exhibiting a range of phenotypes and functions as they react to diverse stimuli within their local microenvironment. In recent years, there has been an increasing number of studies on the regulation of macrophage behavior based on tissue engineering strategies, and its regulatory mechanisms deserve further investigation.
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