W'axon, wax off: Striatal cholinergic synapses instruct dopamine axon activity.

Neuron

Department of Neurosurgery, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Published: September 2022

Canonically, axons are considered the output structures of neurons, relaying signals generated at the dendrites and soma. In this issue of Neuron, Kramer et al. challenge this notion by showing that dopaminergic axons can be depolarized directly by cholinergic interneurons and even generate action potentials independent of somatic activity.

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http://dx.doi.org/10.1016/j.neuron.2022.08.023DOI Listing

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