Prevalence of ST1193 Causing Intracranial Infection in Changsha, China.

Trop Med Infect Dis

Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha 410008, China.

Published: August 2022

AI Article Synopsis

  • ST1193 is a new, rapidly spreading clone linked to intracranial infections, specifically identified in Changsha, China.
  • Researchers collected 28 isolates from cerebrospinal fluid over four years, finding ST1193 to be the most prevalent at 28.6%.
  • All ST1193 isolates exhibited resistance to Ciprofloxacin, and the study underscores the need for better surveillance to prevent its spread, especially given the severity of cases among infants.

Article Abstract

ST1193 is an emerging new virulent and resistant clone among with a tendency to spread rapidly across the globe. However, the prevalence of intracranial infection-causing ST1193 is rarely reported. This study aimed at determining the prevalence of ST1193 isolates, causing intracranial infections in Changsha, central China. A total of 28 isolates were collected from the cerebrospinal fluid of patients with intracranial infection over a four-year period. All isolates were differentiated using multilocus sequence typing (MLST), and phylogenetic grouping, and tested for antibiotic resistance. MLST analysis showed 11 sequence types (ST) among the 28 isolates. The most prevalent ST was B2-ST1193 (28.6%, 8/28), followed by B2-ST131 (21.4%, 6/28) and F-ST648 (10.7%, 3/28). Of the eight ST1193 isolates, three carried CTX-M-55, and one carried CTX-M-27. All eight ST1193 isolates were resistant to Ciprofloxacin, showing 1AB/4A mutations. Two ST1193 isolates carried the gene. All ST1193 isolates were recovered from infants with meningitis, with a fatal outcome for one three-month-old infant. ST1193 has emerged as the predominant type of strain causing intracranial infections in Changsha, China. This study highlights the importance of implementing appropriate surveillance measures to prevent the spread of this emerging public health threat.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504535PMC
http://dx.doi.org/10.3390/tropicalmed7090217DOI Listing

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