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Immunoassay interferences: laboratory pitfall in the diagnosis of adrenocortical carcinoma.
BMJ Case Rep
February 2024
Endocrinology, Diabetes and Metabolism, Centro Hospitalar e Universitário de Coimbra EPE, Coimbra, Portugal.
A woman in her late 50s with recent onset of hypertension, diabetes, lumbar pain and unintentional weight loss was diagnosed with a cortisol and androgen-producing adrenal mass. Despite this, serum adrenocorticotropic hormone (ACTH) concentration was inappropriately elevated, which was investigated thoroughly. Investigations included a brain magnetic resonance imaging to exclude concomitant pituitary adenoma, a corticotropin-releasing hormone stimulation test and a gallium- and 18F-FDOPA PET scan, both excluding ectopic ACTH production.
View Article and Find Full Text PDFGiant androgen-producing adrenocortical carcinoma causing male characteristics.
Asian J Surg
January 2024
Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China. Electronic address:
Peripheral precocious puberty in Li-Fraumeni syndrome: a case report and literature review of pure androgen-secreting adrenocortical tumors.
J Med Case Rep
May 2023
Division of Pediatric Endocrinology, Department of Pediatrics, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, 1090, Brussels, Belgium.
Introduction: Pure androgen-secreting adrenocortical tumors are a rare but important cause of peripheral precocious puberty.
Case Presentation: Here, we report a pure androgen-secreting adrenocortical tumor in a 2.5-year-old boy presenting with penile enlargement, pubic hair, frequent erections, and rapid linear growth.
ACTH-independent production of 11-oxygenated androgens and glucocorticoids in an adrenocortical adenoma.
Eur J Endocrinol
December 2022
Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Due to its rarity, biochemical and histologic characteristics of androgen and glucocorticoid co-secreting adrenocortical adenomas are largely unknown. Herein, we report a case of adrenocortical adenoma that caused marked hyperandrogenemia and mild autonomous cortisol secretion. In this study, we investigated serum steroid profiles using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and histologic characteristics of the resected tumor.
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