Among an organism's entry portals, the respiratory tract is one of the most promising routes for non-invasive administration of therapeutics for local and systemic delivery. On the other hand, it is the subtlest to protect from environmental pollution and microbial occurrences. Here, the biokinetics, distribution, and clearance trends of gold ultrasmall-in-nano architectures administered through a single intranasal application have been quantitatively evaluated. Apart from reaching the lung parenchyma, the (bio)degradable nano-architectures are able to translocate as well to secondary organs and be almost completely excreted within 10 days. These findings further support the clinical relevance of plasmonic nanomaterials for oncology and infectious disease treatment and management. Notably, this investigation also provides crucial information regarding the associated risks as a consequence of the pulmonary delivery of nanoparticles.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417912PMC
http://dx.doi.org/10.1039/d0na00521eDOI Listing

Publication Analysis

Top Keywords

gold ultrasmall-in-nano
8
ultrasmall-in-nano architectures
8
biokinetics clearance
4
clearance inhaled
4
inhaled gold
4
architectures organism's
4
organism's entry
4
entry portals
4
portals respiratory
4
respiratory tract
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!