A 38 year old woman presented with burns totaling 45 % total body surface area, following an explosion resulting from manufacturing cannabis wax. Initial debridement, was delayed to hospital day 7 due to hemodynamic instability. Over the course of her, hospitalization, she required multiple debridements and grafting to her lower, extremities; grafted tissue never survived longer than 72 h. Her bilateral lower, extremities began to exhibit visible mold growth. She underwent repeated, debridements down to vitalized tissue only for recurrent necrosis and mold growth to, occur. She underwent serial amputations eventually reaching the level of her midthigh, At this point her clinical condition deteriorated further resulting in multiorgan failure., Ultimately family made the decision to remove her from life support, and she expired, within a few hours. Postmortem analysis identified Rhizopus spp, Fusarium spp, and, Geotrichum candidum. Mucormycosis species are a frequent infector of Cannabis, sativa, which our patient was working with in the inciting explosion. Cutaneous, mucormycosis is a documented but rare manifestation. We propose that the patient's, relatively young age, severity of burns, and exposure to cannabis plants resulted in this, unusual presentation.
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http://dx.doi.org/10.1016/j.idcr.2022.e01613 | DOI Listing |
Int J Dermatol
January 2025
Department of Dermatology and Venereology, Peking University First Hospital, Beijing, China.
J Fungi (Basel)
December 2024
Department of Parasitology-Mycology, CHU de CAEN Normandie, 14000 Caen, France.
Purpose: Mucormycosis is a rare but emerging and life-threatening infection caused by environmental mold, with a mortality rate of 30-70% despite progress in management. A better understanding could improve its management.
Method: We conducted a single-center retrospective study of all cases of mucormycosis observed over a decade at the University Hospital of Caen.
Diagn Microbiol Infect Dis
December 2024
Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anesthesiology and Critical Care and Burn Unit, Paris, France; University of Paris Cité, Paris, France; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, France Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM UMR-S 942 Mascot, Lariboisière Hospital, Paris, France; INI-CRCT Network, Nancy, France; FHU PROMICE, Paris, France. Electronic address:
Mucormycosis is a fungal infection typically affecting immunocompromised patients. Here, we report a severe case of invasive cutaneous and peritoneal mucormycosis caused by Rhizopus microsporus, successfully treated with a combination of antifungal therapy, PD-1 inhibitor, and interferon-gamma. We highlight the importance of personalized immunotherapy in refractory cases of invasive mucormycosis.
View Article and Find Full Text PDFIndian Dermatol Online J
July 2024
Department of Pathology, Lady Hardinge Medical College and Hospitals, New Delhi, India.
Cureus
October 2024
Pathology, NRI Medical College, Guntur, IND.
Background: Mucormycosis, also known as black fungus, is a rare but serious fungal infection caused by mucor that belongs to Zygomycotic species. Mucor is characterized by non-septate, irregularly wide hyphae with right-angle branching. Mucor can infect different systems of the body and manifest differently depending on the location of the infection, which includes pulmonary, gastrointestinal, rhino-cerebral, and cutaneous.
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