AI Article Synopsis
- Female-specific cancers significantly impact women's health globally, prompting this study to analyze mortality rates of breast, cervical, uterine, and ovarian cancers in China compared to other countries with varying socioeconomic statuses.
- A comprehensive longitudinal study was conducted, revealing that cervical and ovarian cancer mortality rates increased in China (2004-2019), while uterine cancer rates decreased sharply, indicating different trends based on geographic and socioeconomic factors.
- Notably, breast and ovarian cancer rates were higher in urban, developed areas, while cervical and uterine cancers showed contrasting trends; there was also an inverse relationship between the age-standardized mortality rates of breast and ovarian cancers and the Human Development Index (HDI).
Article Abstract
Introduction: Female-specific cancers seriously affect physical and psychological health of women worldwide.
Objectives: We aimed to elucidate trends in the age-standardized mortality rates (ASMRs) of breast cancer, cervical cancer, uterine cancer, and ovarian cancer in female populations with different socioeconomic statuses in China and in countries with different Human Development Index (HDI).
Methods: A longitudinal study was performed using the data of cancer death in China and other 39 countries. The mortality rates were standardized with the Segi's world population. Trends in the mortalities were exhibited by estimated annual percentage change (EAPC). Pearson correlation was used to assess the association between EAPC and HDI.
Results: In mainland China, female breast cancer, cervical cancer, uterine cancer, and ovarian cancer accounted for 6.60 %, 4.21 %, 2.50 %, and 2.02 % of cancer death (n = 1,314,040) in women with 1,220,251,032 person-years, respectively. The ASMRs of cervical cancer (EAPC = 3.87 %, P < 0.001) and ovarian cancer (EAPC = 1.81 %, P < 0.001) increased, that of female breast cancer unchanged, whereas that of uterine cancer was extremely higher and rapidly decreased (EAPC = - 7.65 %, P < 0.001), during 2004-2019. The ASMRs of female breast and ovarian cancers were higher in urban and developed regions than in rural and undeveloped regions, in contrast to cervical and uterine cancers. The ASMRs of female breast and ovarian cancers were lower in China than in other countries, in contrast to uterine cancer. The ASMR of cervical cancer decreased, that of uterine cancer increased, in other countries during 2004-2017. EAPCs for the ASMRs of breast and ovarian cancers were inversely correlated to HDI.
Conclusion: The ASMRs of cervical and ovarian cancers increased, in contrast to uterine cancer, in China during socioeconomic transition. Trends in the ASMRs of breast and ovarian cancers were inversely associated with HDI. These data help control female-specific cancers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334254 | PMC |
| http://dx.doi.org/10.1016/j.jare.2022.09.002 | DOI Listing |
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