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A comprehensive evaluation system for ultrasound-guided infusion of human umbilical cord-derived MSCs in liver cirrhosis patients.
Stem Cells Transl Med
November 2024
Department of Hepatobiliary and Pancreatic Surgery Center, Cell Transplantation Center, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, People's Republic of China.
Background: Infusion of mesenchymal stem cells (MSCs) via portal vein is one of the main ways for MSCs transplantation to treat liver cirrhosis (LC). As the tissue of LC showed diffuse fibrosis and thickened Glission sheath, the soft pig-tail catheter, or central venous catheter can not successfully insert the portal vein. Thus, our study used an improved method and performed a relatively comprehensive system to evaluate the effect for human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) transplantation.
View Article and Find Full Text PDFUltrasound guided pediatric caudal dose: a two-center randomized controlled trial.
BMC Anesthesiol
November 2024
Department of Anaesthesia, Dr Radhakrishnan Gandhi Medical College and Hospital, Hamirpur, India.
Background: The drug volume to be used in caudal in pediatric patients has remained an unmet issue since long. We determined the minimum drug volume required to reach T10 level in pediatric patients using ultrasonography and compared it with the already established volume by Armitage formula.
Aim: To determine the minimum effective caudal local anesthetic dose using ultrasound guidance.
Article Synopsis
- The urachus is a leftover structure from fetal development that connects the bladder to the belly button, and cancers arising from it, known as primary urachal carcinoma, are rare but aggressive.
- A case study presents a 48-year-old woman with abdominal pain and a mass, which was diagnosed as squamous cell carcinoma after imaging and biopsy.
- Treatment typically involves surgery to remove the tumor and surrounding tissue to reduce the chance of spreading, but guidelines are sparse due to the rarity of this type of cancer, with current protocols based on limited data.
Therapeutic efficacy and in vivo distribution of human umbilical cord-derived mesenchymal stem cell spheroids transplanted via B-Ultrasound-guided percutaneous portal vein puncture in rhesus monkey models of liver fibrosis.
Stem Cell Res Ther
September 2024
State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650504, China.
Background: Liver fibrosis can progress to end-stage cirrhosis and liver cancer. Mesenchymal stem cells (MSCs) were considered the most promising therapeutic strategy, but most of the MSCs injected intravenously traditionally are trapped in the lungs, rapidly reducing their survival ability. MSC spheroids cultured in 3D have shown higher tolerance to fluid shear stress and better survival than dissociated MSCs.
View Article and Find Full Text PDFRectus Sheath Blocks for Umbilical Hernia Reductions in the Emergency Department: A Case Series.
Clin Pract Cases Emerg Med
August 2024
St. Joseph's Health, Paterson, New Jersey.
Introduction: Rectus sheath blocks have been used for decades in the operating room for analgesia following umbilical surgical procedures. We present the first reported case series of a rectus sheath block used in the emergency department (ED) for the reduction of an umbilical hernia.
Case Series: Four patients presented to the ED for painful, non-reducible umbilical hernias.
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