AI Article Synopsis
- This study investigates how absolute lymphocyte count (ALC) impacts outcomes in patients with HPV-related oropharyngeal cancer before, during, and after treatment.
- The research was based on a retrospective analysis of 197 patients treated between 2006 and 2018, using statistical methods to assess ALC's influence on cancer progression and survival.
- Key findings indicate that a lower baseline ALC is linked to poorer overall survival, while a lower postoperative ALC increases the risk of cancer progression.
Article Abstract
Background: We aim to explore the prognostic role of absolute lymphocyte count (ALC) before, during, and after treatment on oncologic outcomes in human papillomavirus associated oropharyngeal cancer (HPV(+)OPSCC).
Methods: Retrospective cohort at a tertiary center, 2006-2018. Multivariable Cox regressions were used to determine the effect of ALC on risk of progression. Univariate linear regression was performed to determine clinical factors associated with lower ALC.
Results: All 197 patients underwent primary surgery. Mean (SD) ALC nadirs (×10 cells/L) were: baseline (N = 149): 1.69 (0.56); postoperative (N = 126): 1.58 (0.59); post-RT (N = 141): 0.68 (0.35) and long-term (N = 105): 0.88 (0.37). Lower baseline ALC nadir was associated with worse overall survival (HR 3.85, 95%CI: 1.03-14.29, p = 0.04). Lower postoperative ALC nadir was associated with higher risk of progression (HR 2.63, 95%CI: 1.04-6.67, p = 0.04).
Conclusions: Lower baseline ALC is associated with worse survival, whereas lower postoperative ALC is associated with increased risk of progression in surgically treated HPV(+)OPSCC.
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| http://dx.doi.org/10.1002/hed.27198 | DOI Listing |
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