It is significant to design, synthesise and optimise flavonoid derivatives with better anti-inflammatory activity. This study aims to design and synthesise a series of novel 2-phenyl-4H-chromen-4-one compounds with anti-inflammatory; among them, compound was discovered as the best one. And then, the effects of compound on the TLR4/MAPK signalling pathway was carried out , the results indicated that compound could downregulate NO, IL-6, and TNF-α expression, and suppress LPS-induced inflammation by inhibiting the TLR4/MAPK pathways. Furthermore, compound reduced inflammation by a mouse model of LPS-induced inflammatory disease in . The results suggest that compound has the potential against inflammation through regulating TLR4/MAPK pathway and can be assessed further for drug development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518258 | PMC |
| http://dx.doi.org/10.1080/14756366.2022.2124983 | DOI Listing |
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