Background: Novice neurosurgeons require neurosurgical technique training, but the current method is demanding and time consuming. Therefore, it is crucial to perform training using an appropriate and informative method. In this report, we describe our attempts to provide training in neurosurgical techniques using goat brain model and to demonstrate the effectiveness of this model.
Methods: Under general anesthesia, the surgery was performed on a male goat in the prone position. A midline liner skin incision was made in the scalp, six burr holes were drilled, a craniectomy was performed, and the dura was incised in an arcuate fashion. We attempted the interhemispheric approach and a retrosigmoid approach.
Results: It was confirmed that common neurosurgical approaches are achievable in this model. Furthermore, anatomical structures such as nerves and blood vessels were similar to those of humans. Moreover, the goat brain was similar in color and texture to that of humans.
Conclusion: Unlike a cadaver brain, brain requires hemostasis and careful dissection, which provides the surgeons a realistic experience of actual neurosurgery.
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http://dx.doi.org/10.25259/SNI_494_2022 | DOI Listing |
Sci Rep
January 2025
College of Veterinary Medicine, Anhui Agricultural University, Hefei, Anhui, China.
Previous studies have confirmed that methylation regulates gene transcription in the hypothalamus-pituitary-gonadal axis during puberty initiation, but little is known about the regulation of DNA methylation on gene expression in the pineal gland. To screen pineal gland candidate genes related to the onset of goat puberty and regulated by genome methylation, we collected pineal glands from prepubertal and pubertal female goats, then, determined the DNA methylation profile by whole genome bisulfite sequencing and the transcriptome by RNA sequencing on Illumina HiSeqTM2500. We analyzed differentially expressed genes between the Pre group and Pub group using the DESeq2 software (version 1.
View Article and Find Full Text PDFAnat Rec (Hoboken)
January 2025
Center for Anatomy and Functional Morphology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
High-impact headbutting behavior makes the muskox (Ovibos moschatus) a charismatic species. While many theorize how these headbutting bovids might protect their brain during such encounters, few have investigated their claims anatomically. We investigated the anatomical function of digitiform impressions in the bovid brain cavity and their relationship to headbutting.
View Article and Find Full Text PDFCurr Med Imaging
January 2025
Department of Computer Science and Engineering, Pandit Deen Dayal Energy University, Gujarat, Gandhinagar, India.
Background: The BraTS Generalizability Across Tumors (BraTS-GoAT) initiative addresses the critical need for robust and generalizable models in brain tumor segmentation. Despite advancements in automated segmentation techniques, the variability in tumor characteristics and imaging modalities across clinical settings presents a significant challenge.
Objective: This study aims to develop an advanced CNN-based model for brain tumor segmentation that enhances consistency and utility across diverse clinical environments.
CNS Neurosci Ther
December 2024
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, NHC Key Laboratory of Chronobiology, Sichuan University, Chengdu, China.
Background: Preterm white matter injury (PWMI) is the most common type of brain injury in preterm infants, in which, oligodendrocyte progenitor cells (OPCs) are predominantly damaged. In this study, human OPCs (hOPCs) were administered to a fetal goat model of PWMI to examine the differentiation potential and therapeutic effects of the cells on PWMI.
Methods: Preterm goat fetuses were subjected to hypoxic-ischemia (HI) via intermittent umbilical cord occlusion (5 min × 5).
PLoS Negl Trop Dis
December 2024
IVPC UMR754, INRAE, Universite Claude Bernard Lyon 1, EPHE, Université PSL, Lyon, France.
Rift Valley fever (RVF) is one of the major viral arthropod-borne diseases in Africa. In recent decades, RVF virus (RVFV), the causative agent of RVF, has been responsible for multiple outbreaks in West Africa with important consequences on human and animal health. In particular, an outbreak occurred in 2010 after heavy rains in the desertic region of Adrar, Mauritania.
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