Association Between Covid-19 Severity And Residing In High Lead Level Locations.

Introduction: This 2021 retrospective study explored the association between patients that resided in high lead-exposed areas and Covid-19 severity.

Methods: Adults that resided within a metropolitan area hospitalized with Covid-19 at a community hospital between January 2020 and November 2020 were included in the study. Data including patient's age, sex, length of stay, and co-morbid conditions were extracted from the hospital electronic health record. The patients were classified according to severity of disease based on a Covid Severity Index (qCSI) score, using patient's vitals upon admission. Patient locations were classified per EPA mapping for lead exposure from water pipes.

Results: The qCSI score was significantly higher in the high exposure group, with a mean of 4.6 (SD = 4.4), than the low exposure group, which had a mean of 2.1 (SD = 3.2) (p = 0.004). The median risk stratification levels differed significantly (p = 0.006). Length of stay was also significantly greater in the high exposure group, mean 11.4 (SD 10.7), then in the low exposure group, mean 6.2 (SD = 7.2) (p = 0.01).

Conclusion: This study demonstrated an association between Covid-19 severity and patients that have had high lead level exposure. Further research is needed to explore this possible association, such as studies involving larger datasets.