AI Article Synopsis
- The study investigates the link between acute pancreatitis (AP) and Crohn’s disease (CD), assessing whether AP is an extraintestinal manifestation of CD.
- An analysis of data from over 214,000 CD patients revealed that 1.1% had AP, which was linked to a higher risk of inpatient mortality and other health conditions like gallstone disease and nonalcoholic fatty liver disease.
- Findings suggest that patients with CD and AP are more likely to be readmitted for AP within 30 days, indicating that AP is associated with poorer hospitalization outcomes for CD patients.
Article Abstract
Background: Few studies evaluated the risk of acute pancreatitis (AP) in patients with Crohn's disease (CD). It's controversial if AP can be considered as an extraintestinal manifestation of CD. We studied this potential association in a retrospective cohort of patients with CD.
Methods: We draw our cohort from the Nationwide Readmission Databases 2016 - 2018. We used the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes to identify all adult patients admitted with a diagnosis of CD. Patient with a comorbid AP were identified. We analyzed the significant impact of AP on hospitalization outcomes. A multivariate regression analysis was used to identify factors associated with AP.
Results: We included 214,622 patients discharged from an index hospitalization for CD, 1.1% had AP. AP was independently associated with higher odds of inpatient mortality (odds ratio (OR): 1.831; 95% confidence interval (CI): 1.345 - 2.492, P < 0.001), gallstone disease (OR: 4.047; 95% CI: 3.343 - 4.9, P < 0.001), nonalcoholic fatty liver disease (NAFLD) (OR: 3.568; 95% CI: 3.08 - 4.133, P < 0.001), and hypercalcemia (OR: 1.964; 95% CI: 1.302 - 2.965, P = 0.001). Thirty-day readmission analysis showed that CD patients with AP were more commonly to be readmitted for AP than for any other reason.
Conclusions: In our nationwide cohort of CD patients, there was a significant association between AP and worse hospitalization outcomes. Additionally, we found independent associations for having AP that may help identify patients at high risk.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451556 | PMC |
| http://dx.doi.org/10.14740/jocmr4761 | DOI Listing |
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