Background: This study investigated the effect of central administration of α-pinene and the interaction of α-pinene with GABAA receptor on pulpal nociception-induced changes in learning and memory performances in rats.
Materials And Methods: Sixty-six adult male Wistar rats were used. Pulpal nociception was induced by intradental application of capsaicin (100 μg/rat). α-pinene (0.1, 0.2, and 0.4 μg/rat) was injected centrally 10 min before the administration of capsaicin. In addition, α-pinene (0.4 μg/rat) was co-injected with bicuculline (0.5 μg/rat). Spatial and passive avoidance learning and memory were assessed using Morris water maze (MWM) and shuttle box tasks, respectively.
Results: Experimental results of the MWM test showed that capsaicin increases escape latency and distance traveled to the hidden platform ( < 0.01). The effect was prohibited by α-pinene at the dose of 0.4 μg/rat. Moreover, capsaicin-treated animals spent less time in the target zone than capsaicin + α-pinene (0.4 μg/rat)-treated rats ( < 0.05). In the shuttle box test, α-pinene (0.2 μg and 0.4 μg) prevented an increased number of acquisition trials and time spent in the dark chamber induced by capsaicin, whereas it increased step-through latency ( < 0.01). However, the effects of α-pinene (0.4 μg/rat) in both tests were prohibited by bicuculline (0.5 μg/rat).
Conclusion: The data showed that central administration of α-pinene might reduce pulpalgia-induced learning and memory impairment, at least partially, via modulation of GABA receptors.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482378 | PMC |
| http://dx.doi.org/10.4103/abr.abr_139_21 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhancing security and efficiency in Mobile Ad Hoc Networks using a hybrid deep learning model for flooding attack detection.
Sci Rep
January 2025
North Carolina School of Science and Mathematics, Durham, NC, 27705, USA.
Mobile Ad Hoc Networks (MANETs) are increasingly replacing conventional communication systems due to their decentralized and dynamic nature. However, their wireless architecture makes them highly vulnerable to flooding attacks, which can disrupt communication, deplete energy resources, and degrade network performance. This study presents a novel hybrid deep learning approach integrating Convolutional Neural Networks (CNN) with Long Short-Term Memory (LSTM) and Gated Recurrent Unit (GRU) architectures to effectively detect and mitigate flooding attacks in MANETs.
View Article and Find Full Text PDFA comparative study of cognitive impairment in sporadic and familial cases of multiple sclerosis.
Sci Rep
January 2025
Faculty of Computer Science and Engineering, Shahid Beheshti University, Tehran, Iran.
Genetics plays a significant role in Multiple Sclerosis (MS), with approximately 12.6% of cases occurring in familial form. While previous studies have demonstrated differences in disease progression and MRI findings between familial and sporadic MS, there has been no comparison of cognitive impairment between them.
View Article and Find Full Text PDFThe RNA-binding properties of Annexins.
J Mol Biol
January 2025
Elettra Sincrotrone Trieste, Italy; The Wohl Institute, King's College London, 5 Cutcombe Rd, SW59RT London, UK. Electronic address:
Annexins are a family of calcium-dependent phospholipid-binding proteins involved in crucial cellular processes such as cell division, calcium signaling, vesicle trafficking, membrane repair, and apoptosis. In addition to these properties, Annexins have also been shown to bind RNA, although this function is not universally recognized. In the attempt to clarify this important issue, we employed an integrated combination of experimental and computational approaches.
View Article and Find Full Text PDFNumber of subfields of the rat dorsal subiculum defined by the NOS and PCP4 immunoreactivities changes according to the different levels of observation.
Neuroscience
January 2025
Department of Molecular Anatomy, School of Medicine University of the Ryukyus, Uehara, 207, Nishihara, Okinawa 903-0213, Japan.
The subiculum is a main output part of the hippocampal formation and important for learning and memory. According to connection studies, the distal and proximal regions of the subiculum project to the brain regions related to the spatial and emotional memories, respectively. Our previous morphological studies indicated that the ventral subiculum (vSub) consists of two regions, the distal subiculum (Sub1) and the proximal subiculum (Sub2), while the dorsal subiculum (dSub) seemed to comprise only one region (Sub1).
View Article and Find Full Text PDFThe Trail of axonal protein Synthesis: Origins and current functional Landscapes.
Neuroscience
January 2025
Departamento de Genómica, Instituto de Investigaciones Biológicas Clemente Estable, MEC, Av. Italia 3318, Montevideo, CP 11600, Uruguay; Departamento de Biología Celular y Molecular, Facultad de Ciencias, Universidad de la República, Iguá, Montevideo, 4225, CP 11400, Uruguay. Electronic address:
Local protein synthesis (LPS) in axons is now recognized as a physiological process, participating both in the maintenance of axonal function and diverse plastic phenomena. In the last decades of the 20th century, the existence and function of axonal LPS were topics of significant debate. Very early, axonal LPS was thought not to occur at all and was later accepted to play roles only during development or in response to specific conditions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!