AI Article Synopsis
- Optimal selenium (Se) status is crucial for health, influenced by factors like diet, age, sex, and overall health.
- At nutritional levels, Se is vital for the function of various selenoproteins that play roles in redox reactions and metabolic processes.
- Both inadequate and excessive selenium intake may elevate the risk of type 2 diabetes mellitus (T2D), with these risks linked to the functioning of selenoproteins, highlighting the importance of maintaining appropriate selenium levels.
Article Abstract
Optimal selenium (Se) status is necessary for overall health. That status can be affected by food intake pattern, age, sex, and health status. At nutritional levels of intake, Se functions metabolically as an essential constituent of some two dozen selenoproteins, most, if not all, of which have redox functions. Insufficient dietary intake of Se reduces, to varying degrees, the expression of these selenoproteins. Recent clinical and animal studies have indicated that both insufficient and excessive Se intakes may increase risk of type 2 diabetes mellitus (T2D), perhaps by way of selenoprotein actions. In this review, we discuss the current evidence linking Se status and T2D risk, and the roles of 14 selenoproteins and other proteins involved in selenoprotein biosynthesis. Understanding such results can inform the setting of safe and adequate Se intakes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707339 | PMC |
| http://dx.doi.org/10.1016/j.abb.2022.109400 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!