Microbes unculturable in vitro remain diagnostically challenging, dependent historically on clinical findings, histology, or targeted molecular detection. We applied whole-genome sequencing directly from tissue to diagnose infections with mycobacteria (leprosy) and parasites (coenurosis). Direct pathogen DNA sequencing provides flexible solutions to diagnosis of difficult pathogens in diverse contexts.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472670 | PMC |
| http://dx.doi.org/10.1093/ofid/ofac428 | DOI Listing |
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