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| http://dx.doi.org/10.3389/fneur.2022.1004853 | DOI Listing |
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Fatal C-Reactive Protein-less Sepsis with Anti-IL-6 Autoantibody Production after Administration of Durvalumab.
Intern Med
December 2024
Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan.
Durvalumab plus platinum-based chemotherapy is the first-line treatment for extensive-stage small-cell lung cancer. Immune checkpoint inhibitors (durvalumab) can cause immune-related adverse events (irAEs). We herein report the first case of fatal sepsis with anti-interleukin-6 autoantibody production following durvalumab administration.
View Article and Find Full Text PDFAnalysis of Pregnancy Outcomes in Patients Exhibiting Recurrent Miscarriage With Concurrent Low-Titer Antiphospholipid Antibodies.
Am J Reprod Immunol
November 2024
Department of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Article Synopsis
- Antiphospholipid syndrome (APS) is an autoimmune disorder affecting blood clotting and pregnancy outcomes, defined by the presence of antiphospholipid antibodies (aPLs), with recent criteria requiring higher antibody levels for diagnosis.
- This study analyzed the pregnancy outcomes in 252 pregnancies of recurrent miscarriage (RM) patients, focusing on the effects of treatment in those with low-titer aPLs, splitting them into treated and untreated groups.
- Results showed varied positivity rates for different aPL types among treated and untreated patients, suggesting treatment may influence pregnancy success in women with low-titer aPLs, although outcomes were still being assessed.
Pemphigus relapse: Mechanisms, risk factors, and agents associated with disease recurrence.
J Dermatol
December 2024
Department of Dermatology, Rutgers Robert Wood Johnson Medical School, Somerset, New Jersey, USA.
Pemphigus represents a spectrum of potentially life-threatening autoimmune-mediated skin blistering conditions caused by antibody production against desmoglein 1 and 3 (anti-DSG 1 and 3) in keratinocytes. Greater than 50% of pemphigus patients experience relapse, which complicates long-term medical management, including risks associated with re-treatment and complications such as infection and dehydration. This review aims to elucidate mechanisms, risk factors, and medications associated with pemphigus relapse.
View Article and Find Full Text PDFEffectiveness of double-filtration plasmapheresis in reducing immunoglobulin and culprit antibody levels in neuroimmune disorders: A single-center retrospective analysis from China.
J Neuroimmunol
November 2024
Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, PR China. Electronic address:
Article Synopsis
- - This study looks at how effective double-filtration plasmapheresis (DFPP) is in lowering harmful antibodies and immunoglobulins in patients with neuroimmune disorders.
- - Researchers analyzed data from 51 patients who received DFPP along with other treatments, measuring changes in immunoglobulin and antibody levels, and assessing neurological function before and after treatment.
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Elevated serum levels of C-terminal agrin fragment in acetylcholine receptor antibody-positive myasthenia gravis.
J Neuroimmunol
November 2024
Department of Neurology, Graduate School of Medicine, Chiba University, Japan.
Article Synopsis
- * Research showed that serum CAF levels are significantly higher in patients with acetylcholine receptor antibody-positive myasthenia gravis (AChR-MG) compared to healthy individuals, but not in those with muscle-specific kinase antibody-positive myasthenia gravis.
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