Theory of Mind in migraine and medication-overuse headache: A cross-sectional study.

Background: Theory of Mind (ToM) is the ability to predict and anticipate others' behaviors through the mental state attribution process. This study aims to investigate the ToM in patients with medication-overuse headache (MOH) and episodic migraine (EM) and to compare it with healthy controls (HC).

Methods: This study enrolled patients with MOH, patients with EM, and HC. ToM was assessed through the Theory of Mind Assessment Scale (ThOMAS), which includes four subscales: Scale A, I-Me, Scale B, Other-Self, Scale C, I-Other, and Scale D, Other-Me, through the Reading the Mind in the Eyes test (RMET), which measures complex emotion recognition, and through the Toronto Alexithymia Scale (TAS-20), which measures alexithymia. Concomitant psychiatric disturbances were evaluated through the Hamilton Anxiety Rating Scale, the Hamilton Depression Rating Scale, and the Dissociative Experiences Scale-II.

Results: The study involved 21 patients with EM, 22 patients with MOH, and 18 HC. In all the four subscales of the ThOMAS, there was a significant difference between HC, EM, and MOH patients: Scale A ( = 0.009), Scale B ( = 0.004), Scale C ( = 0.039), and Scale D ( = 0.008). In the RMET, MOH patients had worse performances than EM patients and HC ( = 0.039). MOH group exhibited higher levels of alexithymia when compared to the HC ( = 0.033) and higher levels of anxiety than HC ( = 0.001).

Conclusion: MOH patients showed a subtle psychopathological pattern characterized by impaired social adaptation.