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| http://dx.doi.org/10.3389/fgene.2022.967936 | DOI Listing |
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Molecular Insights into the Therapeutic Mechanisms of BuShen-QiangDu-ZhiLv Decoction for Ankylosing Spondylitis.
J Ethnopharmacol
December 2024
Guangzhou University of Chinese Medicine, 510006 Guangzhou, China; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine) 510120 Guangzhou, China; Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese Medicine, 510120 Guangzhou, China. Electronic address:
Ethnopharmacological Relevance: Ankylosing spondylitis (AS) is a chronic rheumatic immune disease characterized by high disability rates, significantly affecting patients' quality of life. BuShen-QiangDu-ZhiLv Decoction (BQZD), developed by the renowned traditional Chinese medicine practitioner Jiao Shude, has been traditionally used for AS treatment. However, the bioactive components and the precise mechanisms underlying BQZD's therapeutic effects remain largely unexplored.
View Article and Find Full Text PDFReallocating Time Between 24-h Movement Behaviors for Obesity Management Across the Lifespan: A Pooled Data Meta-Analysis of More Than 9800 Participants from Seven Countries.
Sports Med
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Australian Catholic University, North Sydney, NSW, Australia.
Article Synopsis
- The study investigates how reallocating time among physical activity, sedentary behavior, and sleep affects obesity indicators like BMI and waist circumference across various age groups.
- Researchers analyzed data from 9,818 participants using isotemporal substitution models to understand the implications of these behavior changes.
- Results indicated that even small shifts of 10-30 minutes can significantly impact obesity, with reallocating moderate-to-vigorous physical activity (MVPA) to lighter activities or sedentary behavior having particularly detrimental effects.
Machine learning approaches for improvement of patient safety in surgery.
Patient Saf Surg
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Mission Health, 509 Biltmore Ave., Asheville, NC, 28801, USA.
A proposal to simplify the definition of pediatric hypertension: bridging the gap between perception and action.
BMC Med
December 2024
Department of Epidemiology/Department of Maternal, Child and Adolescent Care, School of Public Health, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Background: The importance of routine hypertension screening in children and adolescents is now well recognized. However, it is often undiagnosed in clinical practice, partly due to the reliance on a complex blood pressure (BP) percentile-based table with hundreds of cutoffs by age, sex, and height.
Main Text: Many studies have explored simplified tools for screening hypertension in children and adolescents, such as simplified formulas, simplified BP tables by age and sex group, by age group, or by height group, and the BP to height ratio.
ASPH dysregulates cell death and induces chemoresistance in hepatocellular carcinoma.
Cancer Lett
December 2024
Department of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, P.R. China. Electronic address:
Hepatocellular carcinoma (HCC) is resistant to multiple conventional drugs including sorafenib, leading to poor prognosis. Inducing cell death has been inextricably pursued in therapeutics, although targeted therapy and immunotherapy have made very limited progress. ASPH (Aspartate β-hydroxylase) can be breakthrough in meeting this unmet clinical need.
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